Drugs / Fomepizole
Fomepizole
Regulatory milestones approvals, filings & regulatory actions · 2 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Label expansion | US (FDA) | ANTIZOL | — | 2000-12-08 | fda.gov ↗ |
| Approved | US (FDA) | ANTIZOL | — | 1997-12-04 | fda.gov ↗ |
Trials 4 · a red edge is where a trial was stopped
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 01 trial | ||||||
| Phase 0 | NCT03878693 | Jul → Oct 2018 | — | University of Arizona | Completed | No outcome recorded |
| Phase 11 trial | ||||||
| Phase 1 | NCT00346853 | Nov 2005 → May 2006 | macular corneal dystrophy | University of Utah | Completed | No outcome recorded |
| Phase 22 trials | ||||||
| Phase 2 | NCT05517668 | Sep 2022 → Oct 2025 | drug-induced liver injury, liver failure, paracetamol poisoning | Richard Dart, MD, PhD | Terminated | No outcome recorded |
| Phase 2 | NCT00661141 | Apr → Jun 2008 | — | Amgen | Completed | No outcome recorded |
Evidence & citations 9 cited values
Every value below carries the sentence it was read from. 6 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | fomepizole | “4-methylpyrazole (4-MP, fomepizole, Antizol™) inhibits dark adaptation of the eye.” NCT00346853 ↗ |
| Known as | 4-methylpyrazole | “Fomepizole (4-methylpyrazole) is an FDA approved medication for the treatment of patients with toxic alcohol poisoning by blocking the activity of alcohol dehydrogenase.” NCT05517668 ↗ |
| Known as | 4-MP | “4-methylpyrazole (4-MP, fomepizole, Antizol™) inhibits dark adaptation of the eye.” NCT00346853 ↗1“Intravenous infusion of Fomepizole (4-MP)” NCT05517668 ↗ |
| Known as | Antizol | “the Antizol (fomepizole) doses (bags) #1-5 allocated for the study will precisely adhere to the manufacturer's recommendations from the package insert.” NCT05517668 ↗2“4-methylpyrazole (4-MP, fomepizole, Antizol™) inhibits dark adaptation of the eye.” NCT00346853 ↗ |
| Known as | Fomepizol | ChEMBL registry synonym — accepted as the source's own label CHEMBL1308 ↗ |
| Known as | NSC-760365 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1308 ↗ |
| Action | Inhibit | “an alcohol dehydrogenase inhibitor” PMID 17963111 ↗ Oct 2007 |
| Modality | Small molecule | — CHEMBL1308 ↗ |
| Route | Intravenous | “Healthy adults were given intravenous infusions of either 4-MP or placebo” PMID 17963111 ↗ Oct 2007 |