4-methylpyrazole and Acetaminophen Metabolism

NCT03878693 ↗

Phase 0 Completed 6 enrolled University of Arizona

RandomizedSingle-groupOpen-labelOther

Summary

Oxidative metabolism of APAP will be studied with and without 4-MP.

Timeline

Start: 2018-07-01
Primary completion: 2018-10-31
Completion: 2018-10-31

Outcome

Met primary endpoint

paper Compared with APAP alone, co-treatment with 4-MP decreased the percentage of ingested APAP recovered as oxidative metabolites in 24-hour urine from 4.48 to 0.51% PMID 31768936 ↗

paper from 4.48 to 0.51% (95% CI = 2.31-5.63%, p = 0.003). PMID 31768936 ↗

Publications

Kang AM, Padilla-Jones A, Fisher ES, Akakpo JY, Jaeschke H, Rumack BH, Gerkin RD, Curry SC. The Effect of 4-Methylpyrazole on Oxidative Metabolism of Acetaminophen in Human Volunteers. J Med Toxicol. 2020 Apr;16(2):169-176. doi: 10.1007/s13181-019-00740-z. Epub 2019 Nov 25.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Acetaminophen	Small molecule	80 mg/kg	Oral
Subject	Fomepizole	Unknown	—	Intravenous

Indications

No indication recorded.