Drugs / OSORESNONTRINE
last change Aug 2022 re-read 2 minutes ago

OSORESNONTRINE

Small molecule targets PDE9A via inhibition

Developed for
schizophrenia · Alzheimer disease · psychotic disorder
Investigated by
Boehringer Ingelheim

Trials 23 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 118 trials
Phase 1 NCT04602221 Dec 2020 → Aug 2022 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT03934203 May → Sep 2019 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT03505151 Apr → May 2018 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT03193307 Jun → Dec 2017 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT03151499 May → Jul 2017 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT02853136 Aug → Oct 2016 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT02635750 Jan → Mar 2016 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT02597998 Sep → Dec 2015 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT02438683 May → Aug 2015 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT02392468 Apr 2015 → Aug 2017 Alzheimer disease, schizophrenia Boehringer Ingelheim Completed No outcome recorded
Phase 25 trials
Phase 2 NCT03351244 Dec 2017 → Mar 2021 schizophrenia Boehringer Ingelheim Terminated No outcome recorded
Phase 2 NCT03230097 Sep 2017 → Mar 2021 psychotic disorder Boehringer Ingelheim Terminated No outcome recorded
Phase 2 NCT02337907 Jan 2015 → Sep 2017 Alzheimer disease Boehringer Ingelheim Completed No outcome recorded
Phase 2 NCT02240693 Jan 2015 → Sep 2017 Alzheimer disease Boehringer Ingelheim Completed No outcome recorded
Phase 2 NCT02281773 Nov 2014 → May 2016 schizophrenia Boehringer Ingelheim Completed No outcome recorded

Evidence & citations 9 cited values

Every value below carries the sentence it was read from. 26 sources stand behind the page.

FieldValueCited text
Known as OSORESNONTRINE ChEMBL registry synonym — accepted as the source's own label CHEMBL4206492
Known as BI 409306 ClinicalTrials.gov intervention name — accepted as the source's own label NCT01505894
22

NCT02392468

NCT03151499

NCT02635750

NCT02248259

NCT01841112

NCT01892384

NCT04602221

NCT02337907

NCT02240693

NCT03934203

NCT01611311

NCT02438683

NCT03230097

NCT03505151

NCT01343706

NCT02597998

NCT02853136

NCT02281773

NCT01493570

NCT02222168

NCT03351244

NCT03193307

Known as BI 409306 (C-13/N-15) “On day 1, subjects were administered the Test treatment (T): a single dose of 50 milligram (mg) of BI 409306 film-coated tablet orally with 240 milliliter (mL) of water,...” NCT03505151
Known as Osoresnontrina ChEMBL registry synonym — accepted as the source's own label CHEMBL4206492
Known as SUB 166499 ChEMBL registry synonym — accepted as the source's own label CHEMBL4206492
Action Inhibit “selective phosphodiesterase 9A (PDE9A) inhibitor” PMID 29177699 Nov 2017
Modality Small molecule “a novel phosphodiesterase type 9 inhibitor” PMID 30755255 Feb 2019
Route Oral “administered orally” NCT01343706
Target PDE9A “selective phosphodiesterase 9A (PDE9A) inhibitor” PMID 29177699 Nov 2017