Drugs / NORFLURANE
NORFLURANE
also known as
HFA-134a · hydrofluoroalkane-134a · 1,1,1,2-Tetrafluoroethane · Dymel 134a · Forane 134a · Freon 134a · Genetron 134a · HFA-134A PROPELLANT · +7 more
Trials 3
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 11 trial | ||||||
| Phase 1 | NCT06702462 | Mar → Jun 2025 | asthma | GlaxoSmithKline | Completed | No outcome recorded |
| Phase 32 trials · 1 met primary | ||||||
| Phase 3 | NCT07645248 | Sep 2026 → Feb 2027 expected | asthma | GlaxoSmithKline | Not yet recruiting | No outcome recorded |
| Phase 3 | NCT05850494 | May → Aug 2023 | asthma | AstraZeneca | Completed | Met primary |
| Comparator or background therapy1 trial | ||||||
| Phase 3 | NCT05755932 Comparator | Jun 2023 → Jul 2024 | mucus inspissation of respiratory tract | AstraZeneca | Completed | No outcome recorded |
News releases announcing trial results or a regulatory action · 3
| Date | Issuer | Release |
|---|---|---|
| 2025-11-26 | Chiesi Farmaceutici S.p.A. | Results Chiesi Advanced Carbon Minimal Inhaler (CMI) Program with New Therapeutic Equivalence Data Presented at British Thoracic Society (BTS) Winter Meeting chiesi.com ↗
The findings confirm that Chiesi’s beclometasone dipropionate/formoterol fumarate product formulated with hydrofluoroalkane ( HFA) 152a , delivers comparable clinical efficacy and safety to the currently marketed formulation using HFA-134a 1 . |
| 2025-10-22 | GlaxoSmithKline | Results GSK announces positive pivotal phase III data for next-generation low carbon version of Ventolin (salbutamol) metered dose inhaler gsk.com ↗
Data confirm that the formulation of salbutamol MDI containing an innovative low carbon propellant HFA-152a shows therapeutic equivalence and is comparable in safety to salbutamol MDI containing the current propellant, HFA-134a. |
| 2024-09-03 | Chiesi Farmaceutici S.p.A. | Results Chiesi Group Unveils Innovations in Respiratory Care, Patient Insights into Decentralization of a Clinical Trial and Developments in Carbon Minimal Inhaler Project at ERS Congress 2024 chiesi.com ↗
These studies collectively provided reassuring evidence of a similar performance, safety and tolerability of the new formulations, when compared to the current one, enabling a seamless and safe transition for patients and healthcare systems while significantly reducing environmental impact. |
All press releases naming this drug 3 releases
| Date | Issuer | Release |
|---|---|---|
| 2025-11-26 | Chiesi Farmaceutici S.p.A. | Chiesi Advanced Carbon Minimal Inhaler (CMI) Program with New Therapeutic Equivalence Data Presented at British Thoracic Society (BTS) Winter Meeting chiesi.com ↗ |
| 2025-10-22 | GlaxoSmithKline | GSK announces positive pivotal phase III data for next-generation low carbon version of Ventolin (salbutamol) metered dose inhaler gsk.com ↗ |
| 2024-09-03 | Chiesi Farmaceutici S.p.A. | Chiesi Group Unveils Innovations in Respiratory Care, Patient Insights into Decentralization of a Clinical Trial and Developments in Carbon Minimal Inhaler Project at ERS Congress 2024 chiesi.com ↗ |
Evidence & citations 18 cited values
Every value below carries the sentence it was read from. 6 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | NORFLURANE | ChEMBL registry synonym — accepted as the source's own label CHEMBL2104432 ↗ |
| Known as | 1,1,1,2-Tetrafluoroethane | “1,1,1,2-Tetrafluoroethane [HFA-134a]” NCT06702462 ↗ |
| Known as | Dymel 134a | ChEMBL registry synonym — accepted as the source's own label CHEMBL2104432 ↗ |
| Known as | Forane 134a | ChEMBL registry synonym — accepted as the source's own label CHEMBL2104432 ↗ |
| Known as | Freon 134a | ChEMBL registry synonym — accepted as the source's own label CHEMBL2104432 ↗ |
| Known as | Genetron 134a | ChEMBL registry synonym — accepted as the source's own label CHEMBL2104432 ↗ |
| Known as | HFA-134a | “hydrofluoroalkane-134a (HFA-134a).” PMID 40551410 ↗ Jun 2025 |
| Known as | HFA-134A PROPELLANT | ChEMBL registry synonym — accepted as the source's own label CHEMBL2104432 ↗ |
| Known as | HFC-134A | ChEMBL registry synonym — accepted as the source's own label CHEMBL2104432 ↗ |
| Known as | hydrofluoroalkane-134a | “propellants, such as hydrofluoroalkane-134a (HFA-134a), with global warming potential (GWP) that contribute to the climate emergency.” PMID 42461285 ↗ Jul 20261“hydrofluoroalkane-134a (HFA-134a).” PMID 40551410 ↗ Jun 2025 |
| Known as | Hydrofluorocarbon 134a | ChEMBL registry synonym — accepted as the source's own label CHEMBL2104432 ↗ |
| Known as | Norflurano | ChEMBL registry synonym — accepted as the source's own label CHEMBL2104432 ↗ |
| Known as | R-134A | ChEMBL registry synonym — accepted as the source's own label CHEMBL2104432 ↗ |
| Known as | Solkane 134a | ChEMBL registry synonym — accepted as the source's own label CHEMBL2104432 ↗ |
| Known as | Suva 134a | ChEMBL registry synonym — accepted as the source's own label CHEMBL2104432 ↗ |
| Known as | Tetrafluoroethane | ChEMBL registry synonym — accepted as the source's own label CHEMBL2104432 ↗ |
| Modality | Other / unclassified | “propellants, such as hydrofluoroalkane-134a” PMID 42461285 ↗ Jul 2026 |
| Route | Inhaled | “Route of administration: Oral inhalation” NCT05755932 ↗ |