Drugs / Clostridium butyricum
last change May 2026 re-read 2 minutes ago

Clostridium butyricum

also known as C butyricum · MIYA-BM · MIYAIRI 588 strain

Other / unclassified

Developed for
dyspepsia · chemotherapy-induced toxicity · gastritis · anxiety · bladder transitional cell carcinoma · cancer-related condition · cirrhosis of liver · colonic neoplasm
+7 more · colorectal adenoma · depressive disorder · Helicobacter pylori infectious disease · irritable bowel syndrome · nutritional disorder · peptic ulcer disease · urinary bladder carcinoma
Investigated by
Shandong University · Xijing Hospital of Digestive Diseases · Dongying People's Hospital · Linyi People's Hospital · Qianfoshan Hospital · Rizhao People's Hospital
+18 more · Shandong Cancer Hospital and Institute · Taian City Central Hospital · The Affiliated Hospital of Qingdao University · Weifang People's Hospital · Yantai Yuhuangding Hospital · Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Chang Gung Memorial Hospital · First Affiliated Hospital of Zhejiang University · Jining First People's Hospital · Peking University People's Hospital · Qilu Hospital of Shandong University · Qingdao Eastsea Pharmaceutical Co., Ltd. · Second Affiliated Hospital, School of Medicine, Zhejiang University · Shandong Provincial Hospital · The Affiliated Hospital of Shandong Second Medical University · The First Affiliated Hospital of Bengbu Medical University · The First Affiliated Hospital with Nanjing Medical University · chenxu

Trials 13 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 12 trials
Phase 1 NCT02254629 Jul 2014 → Aug 2015 irritable bowel syndrome Shandong University Completed No outcome recorded
Phase 1 NCT02169388 Jun → Oct 2014 chemotherapy-induced toxicity, colorectal cancer, nutritional disorder Shandong University Unknown No outcome recorded
Phase 23 trials
Phase 2 NCT07474064 Mar 2026 → Mar 2031 expected urinary bladder carcinoma chenxu Not yet recruiting No outcome recorded
Phase 2 NCT06696742 Feb 2024 → Feb 2029 expected bladder transitional cell carcinoma The First Affiliated Hospital with Nanjing Medical University Recruiting No outcome recorded
Phase 2 NCT05914389 Aug 2023 → Aug 2025 overdue colonic neoplasm Second Affiliated Hospital, School of Medicine, Zhejiang University Recruiting No outcome recorded
Phase 47 trials
Phase 4 NCT07167342 May 2026 → Apr 2030 expected colorectal adenoma The Affiliated Hospital of Qingdao University Recruiting No outcome recorded
Phase 4 NCT07152886 Oct 2025 → Oct 2027 expected chemotherapy-induced toxicity, colorectal cancer The Affiliated Hospital of Qingdao University Not yet recruiting No outcome recorded
Phase 4 NCT07182890 Sep 2025 → Oct 2026 expected anxiety, depressive disorder, dyspepsia Xijing Hospital of Digestive Diseases Recruiting No outcome recorded
Phase 4 NCT05237115 May → Dec 2020 dyspepsia, gastritis, peptic ulcer disease Xijing Hospital of Digestive Diseases Completed No outcome recorded
Phase 4 NCT05687409 Nov 2019 → May 2021 cirrhosis of liver, metagonimiasis First Affiliated Hospital of Zhejiang University Completed No outcome recorded
Phase 4 NCT03857425 Mar → Aug 2019 Helicobacter pylori infectious disease, dyspepsia, gastritis Xijing Hospital of Digestive Diseases Completed No outcome recorded
Phase 4 NCT02614963 Dec 2015 → Jul 2016 Shandong University Unknown No outcome recorded
Phase not applicable1 trial
NCT06998823 Mar 2024 → Oct 2025 overdue cancer-related condition Chang Gung Memorial Hospital Recruiting No outcome recorded
Also used as a comparator or background therapy in 1 trial
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 3 NCT00947336 Comparator Apr 2005 → Apr 2008 cirrhosis of liver Govind Ballabh Pant Hospital Completed No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 14 sources stand behind the page.

FieldValueCited text
Known as Clostridium butyricum “A 10-g packet of lactulose oral solution and three capsules of probiotics (each containing \> 4.2×106 CFU Clostridium butyricum and \> 4.2×105 CFU Bifidobacterium longum infantis).” NCT05687409
13

“synbiotic capsules (Streptococcus faecalis JPC 30 million, Clostridium butyricum 2 million, Bacillus mesentericus JPC 1 million, Lactobacillus sporogenes 50 million spores)” NCT00947336

“This study aimed to assess the efficacy and safety of monotherapy with Clostridium butyricum (C butyricum) and Bacillus coagulans (B coagulans) for H pylori treatment.” PMID 33157939 Nov 2020

Clostridium butyricum is a spore-forming bacillus named for its capacity to produce high amounts of butyric acid and is found in soil.” NCT06998823

“oral probiotics (Clostridium butyricum) work to improve the efficacy” NCT07474064

“( clostridium butyricum)” NCT02169388

NCT07167342

NCT07152886

NCT07182890

NCT02254629

NCT05237115

NCT05914389

NCT02614963

NCT06696742

Known as C butyricum “This study aimed to assess the efficacy and safety of monotherapy with Clostridium butyricum (C butyricum) and Bacillus coagulans (B coagulans) for H pylori treatment.” PMID 33157939 Nov 2020
Known as MIYA-BM “Clostridium butyricum MIYAIRI 588 strain (MIYA-BM) is widely used as probiotic therapy to improve symptoms related to dysbiosis such as constipation, nonantimicrobial diarrhea,...” NCT06998823
Known as MIYAIRI 588 strain “Clostridium butyricum MIYAIRI 588 strain (MIYA-BM) is widely used as probiotic therapy to improve symptoms related to dysbiosis such as constipation, nonantimicrobial diarrhea,...” NCT06998823
Action Inhibit “CONCLUSION: C butyricum and B coagulans may effectively inhibit H pylori to some extent, with rare adverse events, and thus may reduce the burden of antibiotic resistance.” PMID 33157939 Nov 2020
Modality Other / unclassified “Probiotic Clostridium Butyricum” NCT02254629
Route Oral “Participants orally administered the contents three times daily after meals” NCT05687409