Drugs / SHR2554

Trials 31

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 110 trials
Phase 1 NCT06712173 Dec 2024 → Sep 2025 overdue peripheral T-cell lymphoma, not otherwise specified Institute of Hematology & Blood Diseases Hospital, China Not yet recruiting No outcome recorded
Phase 1 NCT06093945 Nov 2023 cancer Jiangsu HengRui Medicine Co., Ltd. Completed No outcome recorded
Phase 1 NCT06010680 Oct → Nov 2023 lymphoma Jiangsu HengRui Medicine Co., Ltd. Completed No outcome recorded
Phase 1 NCT05661591 Feb → Mar 2023 cancer Jiangsu HengRui Medicine Co., Ltd. Completed No outcome recorded
Phase 1 NCT05592262 Nov → Dec 2022 cancer Jiangsu HengRui Medicine Co., Ltd. Completed No outcome recorded
Phase 1 NCT05049083 Dec 2021 → Jan 2022 lymphoma Jiangsu HengRui Medicine Co., Ltd. Unknown No outcome recorded
Phase 1 NCT04627129 Jun → Oct 2020 — Jiangsu HengRui Medicine Co., Ltd. Completed No outcome recorded
Phase 1 NCT04577885 May → Aug 2020 — Jiangsu HengRui Medicine Co., Ltd. Completed No outcome recorded
Phase 1 NCT04335266 Aug → Sep 2019 — Jiangsu HengRui Medicine Co., Ltd. Completed No outcome recorded
Phase 1 NCT03603951 Aug 2018 → Feb 2026 overdue lymphoid neoplasm Jiangsu HengRui Medicine Co., Ltd. Active not recruiting No outcome recorded
Phase 1/28 trials
Phase 1/2 NCT07615283 May 2026 → May 2030 expected mature T-cell and NK-cell non-Hodgkin lymphoma, peripheral T-cell lymphoma, not otherwise specified Sun Yat-sen University Not yet recruiting No outcome recorded
Phase 1/2 NCT06568094 Sep 2024 → Dec 2026 expected prostate cancer Jiangsu HengRui Medicine Co., Ltd. Recruiting No outcome recorded
Phase 1/2 NCT06173999 Dec 2023 → Dec 2025 peripheral T-cell lymphoma, not otherwise specified Jiangsu HengRui Medicine Co., Ltd. Unknown No outcome recorded
Phase 1/2 NCT05896046 Jun 2023 → Jun 2025 Hodgkins lymphoma Chinese PLA General Hospital Unknown No outcome recorded
Phase 1/2 NCT05559008 Sep 2022 → Mar 2024 peripheral T-cell lymphoma, not otherwise specified Ruijin Hospital Unknown No outcome recorded
Phase 1/2 NCT04407741 Sep 2020 → Dec 2024 cancer, lymphoma Chinese PLA General Hospital Unknown No outcome recorded
Phase 1/2 NCT03741712 Nov 2018 → Sep 2019 castration-resistant prostate carcinoma Jiangsu HengRui Medicine Co., Ltd. Terminated No outcome recorded
Phase 1/2 NCT03805399 Oct 2018 → Dec 2022 triple-negative breast carcinoma Fudan University Unknown No outcome recorded
Phase 212 trials
Phase 2 NCT07575412 Jun 2026 → Jun 2029 expected acute lymphoblastic leukemia, acute myeloid leukemia, myelodysplastic syndrome The First Affiliated Hospital of Soochow University Not yet recruiting No outcome recorded
Phase 2 NCT07562568 Jun 2026 → Jun 2030 expected acute lymphoblastic leukemia, acute myeloid leukemia, myelodysplastic syndrome The First Affiliated Hospital of Soochow University Not yet recruiting No outcome recorded
Phase 2 NCT07347288 Feb 2026 → Feb 2029 expected — The First Affiliated Hospital with Nanjing Medical University Not yet recruiting No outcome recorded
Phase 2 NCT07230106 Dec 2025 → Dec 2028 expected prostate cancer Jiangsu HengRui Medicine Co., Ltd. Recruiting No outcome recorded
Phase 2 NCT07175220 Oct 2025 → Oct 2028 expected non-small cell lung carcinoma Jiangsu HengRui Medicine Co., Ltd. Recruiting No outcome recorded
Phase 2 NCT07125950 Sep 2025 → Sep 2027 expected breast cancer Henan Cancer Hospital Not yet recruiting No outcome recorded
Phase 2 NCT07102901 Sep 2025 → Dec 2027 expected gastric cancer, gastroesophageal junction adenocarcinoma Jiangsu HengRui Medicine Co., Ltd. Recruiting No outcome recorded
Phase 2 NCT07294664 Jun 2025 → Jul 2027 expected gastric cancer The First Affiliated Hospital of Zhengzhou University Recruiting No outcome recorded
Phase 2 NCT06679673 Dec 2024 → Dec 2025 overdue colorectal cancer Fudan University Not yet recruiting No outcome recorded
Phase 2 NCT06519526 Aug 2024 → Feb 2027 expected peripheral T-cell lymphoma, not otherwise specified Fudan University Recruiting No outcome recorded
Phase 31 trial
Phase 3 NCT06122389 Feb 2024 → May 2026 overdue peripheral T-cell lymphoma, not otherwise specified Jiangsu HengRui Medicine Co., Ltd. Recruiting No outcome recorded
Comparator or background therapy1 trial
Phase 2 NCT07311408 Comparator Jan 2026 → Jan 2028 expected gastric cancer, gastroesophageal junction adenocarcinoma Jingdong Zhang Recruiting No outcome recorded

News releases announcing trial results or a regulatory action · 1

DateIssuerRelease
2026-06-15 Jiangsu HengRui Medicine Co., Ltd. Results 2026 EHA|恒瑞创新药海曲泊帕、立康可泮、泽美妥司他等10余项血液学最新研究成果亮相 hengrui.com ↗
截至2026年1月28日,10例患者可评估疗效(4mg组6例,8mg组4例),最佳ORR为40.0%(4/10),DCR为80.0%(8/10),其中CR 2例,PR 2例。

All press releases naming this drug 1 release

DateIssuerRelease

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 33 sources stand behind the page.

FieldValueCited text
Known as SHR-2554 “combined with EZH2 inhibitor SHR2554 300mg bid continuously” NCT03805399 ↗
31

NCT07311408 ↗

NCT07125950 ↗

NCT07102901 ↗

NCT05661591 ↗

NCT03603951 ↗

NCT04335266 ↗

NCT07562568 ↗

NCT04355858 ↗

NCT04627129 ↗

NCT06010680 ↗

Show 21 more sources

Action Inhibit “SHR2554 is a selective small molecule inhibitor of the histone-lysine methyltransferase EZH2.” NCT03603951 ↗
Modality Small molecule “SHR2554 is a selective small molecule inhibitor of the histone-lysine methyltransferase EZH2.” NCT03603951 ↗
Route Oral “SHR2554 is an oral inhibitor against EZH2” PMID 38190117 ↗ Apr 2024
Target EZH2 “inhibitor of the histone-lysine methyltransferase EZH2” NCT03603951 ↗