Drugs / SHR2554

Trials 31 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 110 trials
Phase 1 NCT06712173 Dec 2024 → Sep 2025 overdue peripheral T-cell lymphoma, not otherwise specified Institute of Hematology & Blood Diseases Hospital, China Not yet recruiting No outcome recorded
Phase 1 NCT06093945 Nov 2023 cancer Jiangsu HengRui Medicine Co., Ltd. Completed No outcome recorded
Phase 1 NCT06010680 Oct → Nov 2023 lymphoma Jiangsu HengRui Medicine Co., Ltd. Completed No outcome recorded
Phase 1 NCT05661591 Feb → Mar 2023 cancer Jiangsu HengRui Medicine Co., Ltd. Completed No outcome recorded
Phase 1 NCT05592262 Nov → Dec 2022 cancer Jiangsu HengRui Medicine Co., Ltd. Completed No outcome recorded
Phase 1 NCT05049083 Dec 2021 → Jan 2022 lymphoma Jiangsu HengRui Medicine Co., Ltd. Unknown No outcome recorded
Phase 1 NCT04627129 Jun → Oct 2020 Jiangsu HengRui Medicine Co., Ltd. Completed No outcome recorded
Phase 1 NCT04577885 May → Aug 2020 Jiangsu HengRui Medicine Co., Ltd. Completed No outcome recorded
Phase 1 NCT04335266 Aug → Sep 2019 Jiangsu HengRui Medicine Co., Ltd. Completed No outcome recorded
Phase 1 NCT03603951 Aug 2018 → Feb 2026 overdue lymphoid neoplasm Jiangsu HengRui Medicine Co., Ltd. Active not recruiting No outcome recorded
Phase 1/28 trials
Phase 1/2 NCT07615283 May 2026 → May 2030 expected mature T-cell and NK-cell non-Hodgkin lymphoma, peripheral T-cell lymphoma, not otherwise specified Sun Yat-sen University Not yet recruiting No outcome recorded
Phase 1/2 NCT06568094 Sep 2024 → Jun 2026 overdue prostate cancer Jiangsu HengRui Medicine Co., Ltd. Recruiting No outcome recorded
Phase 1/2 NCT06173999 Dec 2023 → Dec 2025 peripheral T-cell lymphoma, not otherwise specified Jiangsu HengRui Medicine Co., Ltd. Unknown No outcome recorded
Phase 1/2 NCT05896046 Jun 2023 → Jun 2025 Hodgkins lymphoma Chinese PLA General Hospital Unknown No outcome recorded
Phase 1/2 NCT05559008 Sep 2022 → Mar 2024 peripheral T-cell lymphoma, not otherwise specified Ruijin Hospital Unknown No outcome recorded
Phase 1/2 NCT04407741 Sep 2020 → Dec 2024 cancer, lymphoma Chinese PLA General Hospital Unknown No outcome recorded
Phase 1/2 NCT03741712 Nov 2018 → Sep 2019 castration-resistant prostate carcinoma Jiangsu HengRui Medicine Co., Ltd. Terminated No outcome recorded
Phase 1/2 NCT03805399 Oct 2018 → Dec 2022 triple-negative breast carcinoma Fudan University Unknown No outcome recorded
Phase 212 trials
Phase 2 NCT07562568 Jun 2026 → Jun 2030 expected acute lymphoblastic leukemia, acute myeloid leukemia, myelodysplastic syndrome The First Affiliated Hospital of Soochow University Not yet recruiting No outcome recorded
Phase 2 NCT07575412 Jun 2026 → Jun 2029 expected acute lymphoblastic leukemia, acute myeloid leukemia, myelodysplastic syndrome The First Affiliated Hospital of Soochow University Not yet recruiting No outcome recorded
Phase 2 NCT07347288 Feb 2026 → Feb 2029 expected The First Affiliated Hospital with Nanjing Medical University Not yet recruiting No outcome recorded
Phase 2 NCT07230106 Dec 2025 → Dec 2028 expected prostate cancer Jiangsu HengRui Medicine Co., Ltd. Recruiting No outcome recorded
Phase 2 NCT07175220 Oct 2025 → Oct 2028 expected non-small cell lung carcinoma Jiangsu HengRui Medicine Co., Ltd. Recruiting No outcome recorded
Phase 2 NCT07125950 Sep 2025 → Sep 2027 expected breast cancer Henan Cancer Hospital Not yet recruiting No outcome recorded
Phase 2 NCT07102901 Sep 2025 → Dec 2027 expected gastric cancer, gastroesophageal junction adenocarcinoma Jiangsu HengRui Medicine Co., Ltd. Recruiting No outcome recorded
Phase 2 NCT07294664 Jun 2025 → Jul 2027 expected gastric cancer The First Affiliated Hospital of Zhengzhou University Recruiting No outcome recorded
Phase 2 NCT06679673 Dec 2024 → Dec 2025 overdue colorectal cancer Fudan University Not yet recruiting No outcome recorded
Phase 2 NCT06519526 Aug 2024 → Feb 2027 expected peripheral T-cell lymphoma, not otherwise specified Fudan University Recruiting No outcome recorded
Phase 31 trial
Phase 3 NCT06122389 Feb 2024 → May 2026 overdue peripheral T-cell lymphoma, not otherwise specified Jiangsu HengRui Medicine Co., Ltd. Recruiting No outcome recorded
Also used as a comparator or background therapy in 1 trial
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 2 NCT07311408 Comparator Jan 2026 → Jan 2028 expected gastric cancer, gastroesophageal junction adenocarcinoma Jingdong Zhang Recruiting No outcome recorded

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 33 sources stand behind the page.

FieldValueCited text
Known as SHR2554 “combined with EZH2 inhibitor SHR2554 300mg bid continuously” NCT03805399
31

NCT06010680

NCT07311408

NCT06093945

NCT05592262

NCT06173999

NCT07562568

NCT07102901

NCT06712173

NCT05049083

NCT07615283

NCT07230106

NCT06368167

NCT04577885

NCT03603951

NCT04355858

NCT04627129

NCT06679673

NCT06122389

NCT03741712

NCT04335266

NCT05559008

NCT05896046

NCT04407741

NCT06568094

NCT07347288

NCT05661591

NCT07294664

NCT07175220

NCT07575412

NCT06519526

NCT07125950

Action Inhibit “SHR2554 is a selective small molecule inhibitor of the histone-lysine methyltransferase EZH2.” NCT03603951
Modality Small molecule “SHR2554 is a selective small molecule inhibitor of the histone-lysine methyltransferase EZH2.” NCT03603951
Route Oral “SHR2554 is an oral inhibitor against EZH2” PMID 38190117 Apr 2024
Target EZH2 “inhibitor of the histone-lysine methyltransferase EZH2NCT03603951