Drugs / INCA033989
last change Jul 2026 re-read 2 minutes ago

INCA033989

Developed for
myeloproliferative neoplasm · essential thrombocythemia
Investigated by
Incyte Corporation

Trials 4 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 13 trials
Phase 1 NCT07448155 Mar → Oct 2026 expected Incyte Corporation Recruiting No outcome recorded
Phase 1 NCT06034002 Dec 2023 → Oct 2028 expected myeloproliferative neoplasm Incyte Corporation Recruiting No outcome recorded
Phase 1 NCT05936359 Sep 2023 → Feb 2028 expected myeloproliferative neoplasm Incyte Corporation Recruiting No outcome recorded
Phase 31 trial
Phase 3 NCT07623200 Jul 2026 → Jun 2029 expected essential thrombocythemia Incyte Corporation Not yet recruiting No outcome recorded

Press releases naming this drug 6 releases

DateIssuerRelease
2026-06-13 Incyte Corporation Incyte Announces New Positive Data at EHA 2026 Showed INCA033989 Achieved Rapid, Robust and Sustained Clinical and Molecular Responses and Was Well Tolerated in Patients with Myelofibrosis and Essential Thrombocythemia incyte.com
2025-12-08 Incyte Corporation Incyte Presents Updated Positive Data at ASH 2025 Reinforcing the Potential of INCA033989, its First-in-Class mutCALR-Targeted Monoclonal Antibody, in Patients with Essential Thrombocythemia incyte.com
2025-12-07 Incyte Corporation Incyte’s First-in-Class mutCALR-Targeted Monoclonal Antibody, INCA033989, Granted Breakthrough Therapy Designation by U.S. FDA incyte.com
2025-12-07 Incyte Corporation Incyte Announces New Positive Data for INCA033989, its First-In-Class mutCALR-Targeted Monoclonal Antibody, in Patients with Myelofibrosis Presented at ASH 2025 incyte.com
2025-06-15 Incyte Corporation Positive Late-Breaking Data for Incyte’s First-in-Class mutCALR-targeted therapy INCA033989 in Essential Thrombocythemia Presented at EHA2025 incyte.com
2025-06-03 Incyte Corporation Incyte Announces Multiple Presentations, Including New Late-Breaking Data for its mutCALR-Directed Monoclonal Antibody (INCA033989), Accepted for Presentation at EHA 2025 incyte.com

Evidence & citations 2 cited values

Every value below carries the sentence it was read from. 4 sources stand behind the page.

FieldValueCited text
Known as INCA033989 ClinicalTrials.gov intervention name — accepted as the source's own label NCT07448155
3

NCT07623200

NCT05936359

NCT06034002

Route Subcutaneous “administered as a SC injection” NCT07448155