Drugs / Lanabecestat
last change Jan 2019 re-read 2 minutes ago

Lanabecestat

Small molecule targets BACE1, BACE2 via inhibition

Developed for
Alzheimer disease
Investigated by
AstraZeneca · Eli Lilly and Company · Parexel

Trials 19 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 116 trials
Phase 1 NCT03499041 Jun → Dec 2018 Eli Lilly and Company Withdrawn No outcome recorded
Phase 1 NCT03506399 Jun → Oct 2018 Eli Lilly and Company Withdrawn No outcome recorded
Phase 1 NCT03545087 Jun 2018 → Jan 2019 impaired renal function disease Eli Lilly and Company Withdrawn No outcome recorded
Phase 1 NCT03222427 Jan → Feb 2018 AstraZeneca Completed No outcome recorded
Phase 1 NCT03019549 Jan → May 2017 AstraZeneca Completed No outcome recorded
Phase 1 NCT02663128 Jan → Mar 2016 AstraZeneca Completed No outcome recorded
Phase 1 NCT02568397 Oct 2015 → Jan 2016 AstraZeneca Completed No outcome recorded
Phase 1 NCT02540668 Sep 2015 → Jan 2016 AstraZeneca Completed No outcome recorded
Phase 1 NCT02406261 Apr → Aug 2015 AstraZeneca Completed No outcome recorded
Phase 1 NCT02126514 May 2014 AstraZeneca Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT02245737 Sep 2014 → Oct 2018 Alzheimer disease AstraZeneca Terminated No outcome recorded
Phase 32 trials
Phase 3 NCT02972658 Mar 2017 → Oct 2018 Alzheimer disease AstraZeneca Terminated No outcome recorded
Phase 3 NCT02783573 Jul 2016 → Sep 2018 Alzheimer disease AstraZeneca Terminated No outcome recorded

Evidence & citations 9 cited values

Every value below carries the sentence it was read from. 21 sources stand behind the page.

FieldValueCited text
Known as Lanabecestat ClinicalTrials.gov intervention name — accepted as the source's own label NCT02972658
9

NCT02663128

NCT02245737

NCT03506399

NCT03019549

NCT03545087

NCT02568397

NCT02783573

NCT02540668

NCT02406261

Known as AZD3293 ClinicalTrials.gov intervention name — accepted as the source's own label NCT02039180
6

NCT02040987

NCT02126514

NCT01795339

NCT02010970

NCT01739647

NCT02005211

Known as LANABECESTAT (AZD3293) ChEMBL registry synonym — accepted as the source's own label CHEMBL3989948
Known as LY3314814 “AZD3293 (also known as LY3314814) is a novel, potent, non-selective BACE1/BACE2 inhibitor currently in Phase 3 clinical development for the treatment of Alzheimer's disease.” PMID 29199322 2016
2

NCT03499041

NCT03222427

Action Inhibit “non-selective BACE1/BACE2 inhibitor” PMID 29199322 2016
Modality Small molecule CHEMBL3989948
Route Oral Oral solution” NCT01795339
Target BACE1 “non-selective BACE1/BACE2 inhibitor” PMID 29199322 2016
Target BACE2 “non-selective BACE1/BACE2 inhibitor” PMID 29199322 2016