Drugs / DF-003
last change Jul 2026 re-read 3 minutes ago

DF-003

also known as LP-DF003 · Rp 8br-pet-cgmps

Small molecule targets ALPK1 via inhibition

Developed for
retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and migraine headache syndrome
Investigated by
Shanghai Yao Yuan Biotechnology Ltd.

Trials 2

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1 NCT06395285 May 2025 → Jul 2026 overdue retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and migraine headache syndrome Shanghai Yao Yuan Biotechnology Ltd. Recruiting No outcome recorded
Phase 1 NCT05997641 Sep 2023 → Oct 2026 expected — Shanghai Yao Yuan Biotechnology Ltd. Active not recruiting No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 3 sources stand behind the page.

FieldValueCited text
Known as DF-003 ClinicalTrials.gov intervention name — accepted as the source's own label NCT06395285 ↗
1

NCT05997641 ↗

Known as LP-DF003 ChEMBL registry synonym — accepted as the source's own label CHEMBL1606347 ↗
Known as Rp 8br-pet-cgmps ChEMBL registry synonym — accepted as the source's own label CHEMBL1606347 ↗
Action Inhibit “inhibitor of alpha-kinase 1 (ALPK1)” NCT05997641 ↗
Modality Small molecule “potent small molecule inhibitor” NCT05997641 ↗
Route Oral “Oral administration by capsules” NCT05997641 ↗
Target ALPK1 “inhibitor of alpha-kinase 1 (ALPK1)” NCT05997641 ↗