Drugs / Auranofin

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved US (FDA) RIDAURA 1985-05-24 fda.gov

Trials 13 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT01747798 Nov 2012 → Jan 2014 fallopian tube carcinoma, malignant epithelial tumor of ovary, primary peritoneal carcinoma Mayo Clinic Completed No outcome recorded
Phase 12 trials
Phase 1 NCT02089048 Apr → Sep 2014 amoebiasis due to Entamoeba histolytica National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 1 NCT02126527 Aug 2013 → Sep 2014 cancer of unknown primary site, non-small cell lung carcinoma Mayo Clinic Withdrawn No outcome recorded
Phase 1/23 trials
Phase 1/2 NCT02770378 Nov 2016 → Oct 2018 glioblastoma University of Ulm Completed No outcome recorded
Phase 1/2 NCT01737502 May 2014 → Apr 2023 lung adenocarcinoma, small cell lung carcinoma, squamous cell lung carcinoma Mayo Clinic Completed No outcome recorded
Phase 1/2 NCT02176135 ? → Jan 2016 HIV infectious disease Vaccine and Gene Therapy Institute, Florida Withdrawn No outcome recorded
Phase 26 trials
Phase 2 NCT06805656 Jul 2026 → Jan 2027 expected HIV infectious disease Federal University of São Paulo Not yet recruiting No outcome recorded
Phase 2 NCT03456700 Mar 2018 → Jul 2019 ovarian carcinoma, ovarian serous tumor Mayo Clinic Terminated No outcome recorded
Phase 2 NCT02736968 Nov 2016 → Mar 2021 amebic dysentery, giardiasis National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 2 NCT02968927 Nov 2016 → Sep 2018 tuberculosis The Aurum Institute NPC Unknown No outcome recorded
Phase 2 NCT02063698 Feb 2014 → Nov 2015 Mayo Clinic Completed No outcome recorded
Phase 2 NCT01419691 Sep 2011 → Sep 2015 chronic lymphocytic leukemia/small lymphocytic lymphoma, prolymphocytic leukemia University of Kansas Medical Center Completed No outcome recorded
Phase not applicable1 trial
NCT02961829 Jul 2015 → Mar 2019 HIV infectious disease Federal University of São Paulo Completed No outcome recorded

Evidence & citations 10 cited values

Every value below carries the sentence it was read from. 16 sources stand behind the page.

FieldValueCited text
Known as Auranofin ClinicalTrials.gov intervention name — accepted as the source's own label NCT02770378
12

NCT02961829

NCT02089048

NCT01747798

NCT03456700

NCT02063698

NCT01737502

NCT02736968

NCT02968927

NCT02176135

NCT02126527

NCT01419691

NCT06805656

Known as Auranofina ChEMBL registry synonym — accepted as the source's own label CHEMBL1366
Known as Auranofine ChEMBL registry synonym — accepted as the source's own label CHEMBL1366
Known as NSC-321521 ChEMBL registry synonym — accepted as the source's own label CHEMBL1366
Known as Ridaura “Under an NIH priority to identify new drugs to treat class B parasitic agents, we performed high-throughput screens, which identified the activity of auranofin (Ridaura)...” PMID 27821451 Dec 2016
Known as SK&F 39162 ChEMBL registry synonym — accepted as the source's own label CHEMBL1366
Known as SK-39162 ChEMBL registry synonym — accepted as the source's own label CHEMBL1366
Action Inhibit “This trial served as a proof-of-concept for whether inhibition of protein kinase C iota (PKCι) with auranofin and sirolimus provide antineoplastic effects in patients with...” PMID 41114938 Oct 2025
Modality Small molecule “Auranofin is a gold-containing chemical salt available as 3mg capsules” NCT02736968
Route Oral “Auranofin 6 mg orally in the morning / 6 mg orally in the evening” NCT01419691