Drugs / Paricalcitol
last change Sep 2026 re-read 9 days ago

Paricalcitol

Other / unclassified targets VDR via activation

Developed for
chronic kidney disease · secondary hyperparathyroidism of renal origin · secondary hyperparathyroidism · end stage renal failure · malignant pancreatic neoplasm · pancreatic adenocarcinoma · pancreatic ductal adenocarcinoma · proteinuria
+34 more · anemia · cardiovascular disorder · hypercalcemia disease · vitamin D deficiency · breast cancer · cancer of unknown primary site · chronic pancreatitis · chronic renal failure syndrome · diabetic kidney disease · digestive system carcinoma · Fabry disease · heart failure · hyperparathyroidism · hyperphosphatemia · hypersensitivity reaction disease · IgA glomerulonephritis · kidney disorder · kidney failure · leukemia · malignant exocrine pancreas neoplasm · metastatic malignant neoplasm · myelodysplastic syndrome · peritoneal carcinoma · peritoneal carcinomatosis · plasma cell myeloma · prostate cancer · rectum mucinous adenocarcinoma · type 2 diabetes mellitus · X-linked hypophosphatemic rickets · calcinosis · cardio-renal syndrome · chronic transplant rejection · disease related to solid organ transplantation · infectious disease with sepsis
Investigated by
Abbott · AbbVie · National Cancer Institute (NCI) · Abramson Cancer Center at Penn Medicine · Effice Servicios Para la Investigacion S.L. · HonorHealth Research Institute
+57 more · Lustgarten Foundation · Wake Forest University Health Sciences · Abbott Japan Co.,Ltd · Cedars-Sinai Medical Center · Federico II University · Mario Negri Institute for Pharmacological Research · Massachusetts General Hospital · Roswell Park Cancer Institute · Stand Up To Cancer · The University of Hong Kong · Translational Genomics Research Institute · Washington University School of Medicine · Winthrop University Hospital · American Association for Cancer Research · Amgen · Barts & The London NHS Trust · Barts Cancer Institute · Bristol-Myers Squibb · Cancer Research UK · Cancer Trials Ireland · Chengdu Suncadia Medicine Co., Ltd. · Chinese University of Hong Kong · Dana-Farber Cancer Institute · Emory University · Endeavor Health · Fondazione C.N.R./Regione Toscana "G. Monasterio", Pisa, Italy · Fox Chase Cancer Center · Fundación Renal Iñigo Alvarez De Toledo · Fundación Senefro · Genzyme, a Sanofi Company · Henry Ford Hospital · Hospital Son Espases · Imaging Endpoints · Indiana University · Ipsen · Jaume Arnó Renal Foundation · Laurian Jongejan · M.D. Anderson Cancer Center · Mayo Clinic · Ministry of Health, Malaysia · National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · Northwestern University · OPKO Health, Inc. · Oslo University Hospital · Papageorgiou General Hospital · Patrick Wagner, MD, FACS · Penang Hospital, Malaysia · Peter Rossing · Princeton University · Renal Research Institute · Ricardo Mouzo Mirco · Salk Institute for Biological Studies · Statistika Consultoria Ltda · Thomas Jefferson University · University of California, San Diego · Yale University

Regulatory milestones approvals, filings & regulatory actions · 5 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansions (4) US (FDA) ZEMPLAR — 2000-02-02 – 2016-10-18 fda.gov ↗
Approved US (FDA) ZEMPLAR — 1998-04-17 fda.gov ↗

Trials 72 · started per year

today
US approved 1998
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1998199920002001200220032004200520062007200820092010201120122013201420152016201720182019202020212022202320242025202620272028
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 03 trials
Phase 0 NCT05664880 Jun 2023 → Jun 2026 overdue chronic pancreatitis Cedars-Sinai Medical Center Recruiting No outcome recorded
Phase 0 NCT05365893 Oct 2021 → Dec 2025 overdue pancreatic ductal adenocarcinoma Fox Chase Cancer Center Active not recruiting No outcome recorded
Phase 0 NCT03519308 Jul 2020 → Apr 2022 malignant pancreatic neoplasm Abramson Cancer Center at Penn Medicine Terminated No outcome recorded Stop: Enrollment
Phase 19 trials
Phase 1 NCT03883919 Jul 2019 → Mar 2021 malignant pancreatic neoplasm Washington University School of Medicine Completed No outcome recorded
Phase 1 NCT03520790 Dec 2018 → Jul 2024 malignant pancreatic neoplasm Dana-Farber Cancer Institute Terminated No outcome recorded
Phase 1 NCT03300921 Sep 2017 → Aug 2020 malignant pancreatic neoplasm Abramson Cancer Center at Penn Medicine Terminated No outcome recorded
Phase 1 NCT02930902 Feb 2017 → Jan 2023 digestive system carcinoma, malignant exocrine pancreas neoplasm M.D. Anderson Cancer Center Completed No outcome recorded
Phase 1 NCT02030860 Jan 2014 → Dec 2015 pancreatic adenocarcinoma Abramson Cancer Center at Penn Medicine Completed No outcome recorded
Phase 1 NCT01197664 Aug 2010 → Jul 2012 rectum mucinous adenocarcinoma Wake Forest University Health Sciences Terminated No outcome recorded Stop: Business
Phase 1 NCT00637897 Mar 2008 → Nov 2011 breast cancer Wake Forest University Health Sciences Completed No outcome recorded
Phase 1 NCT00258258 Aug 2005 → Mar 2009 plasma cell myeloma Roswell Park Cancer Institute Terminated No outcome recorded Stop: Enrollment
Phase 1 NCT00217477 Aug 2004 → May 2013 cancer of unknown primary site Roswell Park Cancer Institute Completed No outcome recorded
Phase 218 trials · 1 met primary · 2 missed
Phase 2 NCT07856914 Sep 2026 → Sep 2030 expected peritoneal carcinoma, peritoneal carcinomatosis Patrick Wagner, MD, FACS Not yet recruiting No outcome recorded
Phase 2 NCT04617067 Oct 2020 → Sep 2022 malignant pancreatic neoplasm Cancer Trials Ireland Completed Missed primary
Phase 2 NCT04524702 Sep 2020 → Jun 2023 pancreatic adenocarcinoma Emory University Completed No outcome recorded
Phase 2 NCT04054362 Nov 2018 → Feb 2021 malignant pancreatic neoplasm Barts & The London NHS Trust Completed No outcome recorded
Phase 2 NCT03415854 Jan 2018 → Dec 2023 pancreatic ductal adenocarcinoma HonorHealth Research Institute Completed No outcome recorded
Phase 2 NCT03138720 May 2017 → Jul 2023 pancreatic adenocarcinoma HonorHealth Research Institute Completed No outcome recorded
Phase 2 NCT02754726 Apr 2016 → Apr 2023 pancreatic ductal adenocarcinoma HonorHealth Research Institute Completed No outcome recorded
Phase 2 NCT02686827 Oct 2015 → Apr 2016 hypersensitivity reaction disease Laurian Jongejan Completed No outcome recorded
Phase 2 NCT01393808 Sep 2011 → Jul 2015 type 2 diabetes mellitus Mario Negri Institute for Pharmacological Research Completed Met primary
Phase 2 NCT00990704 Oct 2009 → May 2010 secondary hyperparathyroidism of renal origin Abbott Completed Missed primary
Phase 317 trials · 3 met primary · 1 missed
Phase 3 NCT04994080 Feb 2022 → Mar 2023 secondary hyperparathyroidism of renal origin Chengdu Suncadia Medicine Co., Ltd. Unknown No outcome recorded
Phase 3 NCT04064827 Sep 2020 → Jun 2025 chronic kidney disease, secondary hyperparathyroidism of renal origin AbbVie Terminated No outcome recorded
Phase 3 NCT02282813 Apr 2013 → May 2015 chronic kidney disease, secondary hyperparathyroidism of renal origin, vitamin D deficiency OPKO Health, Inc. Completed No outcome recorded
Phase 3 NCT01694160 Jan 2013 → Jan 2015 proteinuria Oslo University Hospital Completed No outcome recorded
Phase 3 NCT01820767 Aug 2012 → Oct 2013 chronic kidney disease Ricardo Mouzo Mirco Completed No outcome recorded
Phase 3 NCT01382212 Oct 2011 → Apr 2015 end stage renal failure, secondary hyperparathyroidism of renal origin AbbVie Completed No outcome recorded
Phase 3 NCT01680198 Jun 2011 → Aug 2012 chronic kidney disease Fondazione C.N.R./Regione Toscana "G. Monasterio", Pisa, Italy Completed Met primary
Phase 3 NCT01341782 May 2011 → Apr 2012 secondary hyperparathyroidism AbbVie Completed No outcome recorded
Phase 3 NCT01020487 Feb 2010 → May 2014 chronic kidney disease AbbVie Completed Met primary
Phase 3 NCT01012414 Jan 2010 → May 2011 chronic kidney disease, coronary artery disorder, secondary hyperparathyroidism, vitamin D deficiency Thomas Jefferson University Terminated No outcome recorded Stop: Enrollment
Phase 420 trials · 2 met primary
Phase 4 NCT02876211 Dec 2014 → Aug 2022 anemia Hospital Son Espases Terminated No outcome recorded
Phase 4 NCT01939977 Jan 2014 → Sep 2015 secondary hyperparathyroidism of renal origin Fundación Senefro Completed Met primary
Phase 4 NCT01725113 Nov 2012 → Dec 2013 hypercalcemia disease, hyperphosphatemia, kidney failure, secondary hyperparathyroidism Winthrop University Hospital Terminated No outcome recorded Stop: Business
Phase 4 NCT02372695 Jul 2012 → May 2013 — Effice Servicios Para la Investigacion S.L. Terminated No outcome recorded
Phase 4 NCT01506947 May 2012 → Apr 2016 end stage renal failure, secondary hyperparathyroidism AbbVie Completed No outcome recorded
Phase 4 NCT01820078 May 2012 → Sep 2013 chronic kidney disease Fundación Renal Iñigo Alvarez De Toledo Terminated No outcome recorded Stop: Enrollment
Phase 4 NCT03023748 Sep 2011 → Dec 2017 end stage renal failure, secondary hyperparathyroidism of renal origin The University of Hong Kong Unknown No outcome recorded
Phase 4 NCT01768351 Oct 2010 → Mar 2011 anemia, chronic kidney disease Federico II University Completed Met primary
Phase 4 NCT01163162 Aug 2010 → Mar 2011 chronic kidney disease Indiana University Completed No outcome recorded
Phase 4 NCT01331317 Apr 2010 → Apr 2012 cardiovascular disorder, diabetic kidney disease Peter Rossing Completed No outcome recorded
Phase not applicable5 trials · 1 met primary · 2 missed
— NCT01630408 Mar → May 2014 heart failure Massachusetts General Hospital Withdrawn No outcome recorded
— NCT02090608 Mar 2012 → Dec 2013 Fabry disease, proteinuria Federico II University Completed No outcome recorded
— NCT00800358 Nov 2008 → Oct 2009 chronic kidney disease, secondary hyperparathyroidism Penang Hospital, Malaysia Completed Missed primary
— NCT00796679 Oct 2008 → Jun 2011 chronic kidney disease The University of Hong Kong Completed Missed primary
— NCT00469625 Jul 2006 → Jan 2008 proteinuria Winthrop University Hospital Withdrawn Met primary
Comparator or background therapy28 trials
Phase 2 NCT03331562 Comparator Dec 2017 → Jun 2020 pancreatic adenocarcinoma Translational Genomics Research Institute Completed No outcome recorded
Phase 2 NCT01136564 Comparator Jul 2010 → Dec 2011 chronic kidney disease Erling Bjerregaard Pedersen Completed No outcome recorded
Phase 2 NCT01003275 Comparator Oct 2009 → Nov 2011 chronic kidney disease University of Washington Completed No outcome recorded
Phase 2 NCT00421733 Comparator Dec 2006 → Jun 2009 diabetic kidney disease Abbott Completed No outcome recorded
Phase 2/3 NCT01204528 Comparator Sep 2010 → Jun 2013 chronic kidney disease Danderyd Hospital Completed No outcome recorded

News releases announcing trial results or a regulatory action · 1

DateIssuerRelease
2020-03-25 OPKO Health, Inc. Results OPKO Health Reports Interim Results for Two Ongoing RAYALDEE Studies opko.com ↗
The mean iPTH reduction observed so far with RAYALDEE has exceeded 25% from pre-treatment baseline.

All press releases naming this drug 2 releases

DateIssuerRelease

Evidence & citations 11 cited values

Every value below carries the sentence it was read from. 104 sources stand behind the page.

FieldValueCited text
Known as Paricalcitol “Traditional vitamin D therapy (eg, calcitriol, paricalcitol, alfacalcidol, doxercalciferol), to manage secondary hyperparathyroidism (SHPT)” NCT01181531 ↗
95

“Effect Of Paricalcitol (Zemplar) On Endothelial Function And Inflammation In Type 2 Diabetes And Chronic Kidney Disease” NCT01792206 ↗

“effect of oral paricalcitol (2 μg/day) was investigated in 26 patients with non-diabetic, albuminuric stage III-IV CKD.” PMID 23889806 ↗ Jul 2013

“calcitriol and paricalcitol-"Zemplar®") at the maximum dose of 6 mcg/week of paricalcitol("Zemplar®")of equivalent” NCT02273570 ↗

“Patients in the experimental arm received 2 micrograms Paricalcitol capsules daily, for 12 weeks.” NCT01680198 ↗

“Oral paricalcitol was developed to provide a convenient, alternative therapy” NCT00800358 ↗

“Oral paricalcitol, 1 ug/day, plus daily treatment. 6 months (all study)” NCT01820078 ↗

“Paricalcitol (Zemplar)” NCT03138720 ↗

“paricalcitol” NCT00135304 ↗

“Paricalcitol” NCT04054362 ↗

“paricalcitol” NCT00257920 ↗

Show 85 more sources

Known as 19-NOR-1 ALPHA, 25 - (OH)D “Intravenous Paricalcitol (ZEMPLAR™) [19-NOR-1 ALPHA, 25 - (OH)D] With Zoledronic Acid (Zometa™)” NCT00258258 ↗
1

“Paricalcitol (Zemplar™) [19-NOR-1 ALPHA, 25-(OH) D]” NCT00217477 ↗

Known as 19-nor-1,25-dihydroxyvitamin D2 “Recently, paricalcitol (19-nor-1,25-dihydroxyvitamin D2) was approved for the treatment of secondary hyperparathyroidism in chronic renal failure, and the incidence of...” NCT00599963 ↗
1

“The third generation of vitamin D analogues is composed of a group of 1- and 25-hydroxylated vitamin D compounds with either ring structure modifications...” NCT06209268 ↗

Known as COMPOUND 49510 ChEMBL registry synonym — accepted as the source's own label CHEMBL1200622 ↗
Known as Paricalcitol (Zemplar) “Paricalcitol (Zemplar)” NCT03138720 ↗
Known as PCT “testing the effect of VDR activation by paricalcitol (PCT) on endothelium-dependent flow-mediated vasodilatation (FMD)” PMID 29668990 ↗ May 2019
Known as Zemplar “Effect Of Paricalcitol (Zemplar) On Endothelial Function And Inflammation In Type 2 Diabetes And Chronic Kidney Disease” NCT01792206 ↗
15

“calcitriol and paricalcitol-"Zemplar®") at the maximum dose of 6 mcg/week of paricalcitol("Zemplar®")of equivalent” NCT02273570 ↗

“Intravenous Paricalcitol (ZEMPLAR™) [19-NOR-1 ALPHA, 25 - (OH)D] With Zoledronic Acid (Zometa™)” NCT00258258 ↗

“Paricalcitol (Zemplar®) oral capsule , 1 mcg (1 capsule)each 24 hours during 12 months” NCT01442272 ↗

“Paricalcitol (Zemplar™) [19-NOR-1 ALPHA, 25-(OH) D]” NCT00217477 ↗

“Zemplar (paricalcitol) 2ug daily, oral intake” NCT01694160 ↗

“paricalcitol injection (Zemplar)” NCT00053378 ↗

“Zemplar (Paricalcitol injection)” NCT00454350 ↗

“Zemplar (paricalcitol injection)” NCT00062699 ↗

“Zemplar (paricalcitol injection)” NCT00463021 ↗

“Paricalcitol (Zemplar)” NCT03415854 ↗

Show 5 more sources

Action Activate “Selective vitamin D receptor activation with paricalcitol” PMID 21055801 ↗ Nov 2010
Modality Other / unclassified “paricalcitol, a vitamin D analog” PMID 18606901 ↗ Jul 2008
Route Oral “Patients receive oral paricalcitol daily for 4 months” NCT00064376 ↗
Target VDR “VDR activation by paricalcitol (PCT)” PMID 29668990 ↗ May 2019