drugset / Trial / NCT03300921

A Phase Ib Pharmacodynamic Study of Neoadjuvant Paricalcitol in Resectable Pancreatic Cancer A Phase Ib Pharmacodynamic Study of Neoadjuvant Paricalcitol in Resectable Pancreatic Cancer

NCT03300921 ↗

Phase 1 Terminated 3 enrolled Abramson Cancer Center at Penn Medicine
Non-randomizedParallel-groupOpen-labelTreatment

Summary

The main purpose of this study is to look at the potential effects of paricalcitol (a drug similar to vitamin D) on pancreatic tumors in patients who are planned for surgical removal of their tumor. The study will also look at the safety of paricalcitol prior to surgery.

Timeline

Start
2017-09-28
Primary completion
2020-08-30
Completion
2022-03-23

Outcome

Outcome not reported

Stopped: “Newer research suggested that paricalcitol may be harmful to a subset of pancreatic cancer patients and it is not feasible to subtype patients in the short time frame before surgery”

Drugs

EvaluationDrugModalityDoseRoute
Subject Paricalcitol Other / unclassified 12 ug Intravenous
Subject Paricalcitol Other / unclassified 50 ug Intravenous