Drugs / imarikiren
imarikiren
also known as
TAK-272 · IMARIKIREN HYDROCHLORIDE · Imarikirene · Imarikireno · SCO-272 · TAK-272 FREE BASE
Small molecule targets REN via inhibition
Trials 3
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 12 trials | ||||||
| Phase 1 | NCT02367872 | Mar 2015 → Jun 2016 | impaired renal function disease | Takeda | Completed | No outcome recorded |
| Phase 1 | NCT02370615 | Feb → Apr 2015 | — | Takeda | Completed | No outcome recorded |
| Phase 21 trial · 1 met primary | ||||||
| Phase 2 | NCT02332824 | Oct 2014 → Aug 2016 | type 2 diabetes mellitus | Takeda | Completed | Met primary |
Evidence & citations 11 cited values
Every value below carries the sentence it was read from. 4 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | imarikiren | “Imarikiren hydrochloride (TAK-272; SCO-272) is a novel direct renin inhibitor.” PMID 30194585 ↗ Nov 2018 |
| Known as | IMARIKIREN HYDROCHLORIDE | ChEMBL registry synonym — accepted as the source's own label CHEMBL3990145 ↗ |
| Known as | Imarikirene | ChEMBL registry synonym — accepted as the source's own label CHEMBL3990145 ↗ |
| Known as | Imarikireno | ChEMBL registry synonym — accepted as the source's own label CHEMBL3990145 ↗ |
| Known as | SCO-272 | “Imarikiren hydrochloride (TAK-272; SCO-272) is a novel direct renin inhibitor.” PMID 30194585 ↗ Nov 2018 |
| Known as | TAK-272 | “Imarikiren hydrochloride (TAK-272; SCO-272) is a novel direct renin inhibitor.” PMID 30194585 ↗ Nov 2018 |
| Known as | TAK-272 FREE BASE | ChEMBL registry synonym — accepted as the source's own label CHEMBL3990145 ↗ |
| Action | Inhibit | “Imarikiren hydrochloride (TAK-272; SCO-272) is a novel direct renin inhibitor.” PMID 30194585 ↗ Nov 2018 |
| Modality | Small molecule | — CHEMBL3990145 ↗ |
| Route | Oral | “All participants were administered tablets, orally at the same time each day for 12 weeks” NCT02332824 ↗ |
| Target | REN | “Imarikiren hydrochloride (TAK-272; SCO-272) is a novel direct renin inhibitor.” PMID 30194585 ↗ Nov 2018 |