drugset / Trial / NCT02370615
Drug-Drug Interaction Study Between TAK-272 and Itraconazole, Digoxin or Midazolam
Non-randomizedSingle-groupOpen-labelTreatment
Summary
The purpose of this study is to evaluate the effect of repeated-dose administration of itraconazole on the pharmacokinetics of TAK-272, as well as the effect of repeated-dose administration of TAK-272 on the pharmacokinetics of digoxin or midazolam in healthy Japanese adult males.
Timeline
- Start
- 2015-02
- Primary completion
- 2015-04
- Completion
- 2015-04
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Digoxin | Other / unclassified | 0.25 mg | Oral |
| Subject | Itraconazole | Small molecule | 200 mg | Oral |
| Subject | Midazolam | Small molecule | 2 mg | — |
| Subject | imarikiren | Small molecule | 40 mg | Oral |
| Subject | imarikiren | Small molecule | 80 mg | Oral |
Indications
No indication recorded.