Drugs / anti-CD19/BCMA CAR-T cells

Trials 8

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT03824964 Feb 2019 → Jan 2020 B-cell non-Hodgkin lymphoma Allife Medical Science and Technology Co., Ltd. Unknown No outcome recorded
Phase 15 trials
Phase 1 NCT05418088 Jun 2022 → Jul 2027 expected B-cell acute lymphoblastic leukemia, B-cell chronic lymphocytic leukemia, B-cell prolymphocytic leukemia, Richter transformation +2 Sumithira Vasu Recruiting No outcome recorded
Phase 1 NCT03919526 Aug 2019 → Nov 2023 acute lymphoblastic leukemia Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine Completed No outcome recorded
Phase 1 NCT03879382 Feb 2019 → Aug 2020 POEMS syndrome Hrain Biotechnology Co., Ltd. Unknown No outcome recorded
Phase 1 NCT03706547 Oct 2018 → Jul 2020 plasma cell myeloma Peng Liu Unknown No outcome recorded
Phase 1 NCT04303520 May 2018 → Sep 2020 B-cell acute lymphoblastic leukemia The Second Affiliated Hospital of Henan University of Traditional Chinese Medicine Unknown No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT03938987 Mar 2021 → Dec 2026 expected adult acute lymphoblastic leukemia, childhood acute lymphoblastic leukemia University of Alberta Recruiting No outcome recorded
Phase not applicable1 trial
— NCT07121777 Aug 2025 → Aug 2029 expected autoimmune disease Anhui Provincial Hospital Recruiting No outcome recorded

Evidence & citations 13 cited values

Every value below carries the sentence it was read from. 9 sources stand behind the page.

FieldValueCited text
Known as anti-CD19/BCMA CAR-T cells ClinicalTrials.gov intervention name — accepted as the source's own label NCT03879382 ↗
1

NCT03706547 ↗

Known as Anti-CD19/4-1BB/CD3ζ CAR T-cell “Anti-CD19/4-1BB/CD3ζ CAR T-cell: autologous, unselected CD3+ lymphocytes collected from whole blood or apheresis, transfected with a lentiviral vector containing a 2nd...” NCT03938987 ↗
Known as Anti-CD19/BCMA CAR gene vector injection ClinicalTrials.gov intervention name — accepted as the source's own label NCT07121777 ↗
Known as Anti-CD19/CD20/CD22 CAR T-Cells ClinicalTrials.gov intervention name — accepted as the source's own label NCT05418088 ↗
Known as Anti-CD19/CD22 CAR NK Cells ClinicalTrials.gov intervention name — accepted as the source's own label NCT03824964 ↗
Known as anti-CD19/CD22 CAR-T cells ClinicalTrials.gov intervention name — accepted as the source's own label NCT04303520 ↗
1

NCT03919526 ↗

Known as bi-specific CD19-CD22 CAR-T therapy “Collectively, our data advocate for the potential role of bi-specific CD19-CD22 CAR-T therapy in addressing r/r B-ALL.” PMID 40719826 ↗ Jul 2025
Known as CD19-CD22 bi-specific CAR-T therapy “In this study, we present both pre-clinical and clinical findings from an ongoing trial (NCT04303520) assessing the therapeutic efficacy of the CD19-CD22 bi-specific CAR-T...” PMID 40719826 ↗ Jul 2025
Known as CD19-CD22 CAR-T cells “Pre-clinical data from animal models reveal that CD19-CD22 CAR-T cells effectively induce cytotoxicity, thus suppressing B-ALL cell proliferation.” PMID 40719826 ↗ Jul 2025
Action Deplete “bi-specific CAR-T immunotherapies targeting both CD19 and CD22 may offer enhanced efficacy in eliminating r/r B-ALL” PMID 40719826 ↗ Jul 2025
Modality Cell therapy “Retroviral vector-transduced autologous T cells to express anti-CD19 and anti-BCMA CARs” NCT03706547 ↗
Route Intravenous “CAR T-cell intravenous, single dose administration on Day 0” NCT03938987 ↗
Target CD19 “anti-CD19 and anti-BCMA CARs” NCT03706547 ↗