drugset
Drugs / Na-GST-1
last change Jan 2025 re-read 9 days ago

Na-GST-1

also known as N americanus glutathione S-transferase-1 · Necator americanus Glutathione-S-Transferase-1

Protein / enzyme biologic

Developed for
hookworm infectious disease
Investigated by
Baylor College of Medicine · George Washington University · Academic Medical Center - University of Amsterdam · Amsterdam Institute for Global Health and Development · Centre de Recherche Médicale de Lambaréné · Centro de Pesquisas René Rachou
+5 more · Children's National Research Institute · Johns Hopkins University · Leiden University Medical Center · National Institute of Allergy and Infectious Diseases (NIAID) · University of California, San Francisco

Trials 8

today NCT03172975 · Ph 2 NCT03373214 · Ph 1 NCT02839161 · Ph 1 NCT02476773 · Ph 1 NCT02126462 · Ph 1 NCT02143518 · Ph 1 NCT01385189 · Ph 1 NCT01261130 · Ph 1
2012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 17 trials
Phase 1 NCT03373214 Feb 2018 → Feb 2019 hookworm infectious disease Baylor College of Medicine Completed No outcome recorded
Phase 1 NCT02839161 Jan 2017 → Dec 2018 hookworm infectious disease Baylor College of Medicine Completed No outcome recorded
Phase 1 NCT02476773 Jan 2016 → Jun 2017 hookworm infectious disease Baylor College of Medicine Completed No outcome recorded
Phase 1 NCT02126462 Nov 2014 → Feb 2016 hookworm infectious disease Baylor College of Medicine Completed No outcome recorded
Phase 1 NCT02143518 Oct 2014 → Jun 2016 hookworm infectious disease Baylor College of Medicine Completed No outcome recorded
Phase 1 NCT01385189 May 2012 → Jan 2015 hookworm infectious disease Baylor College of Medicine Completed No outcome recorded
Phase 1 NCT01261130 Nov 2011 → Aug 2014 hookworm infectious disease Baylor College of Medicine Completed No outcome recorded
Phase 21 trial · 1 missed
Phase 2 NCT03172975 Mar 2018 → Dec 2024 hookworm infectious disease Baylor College of Medicine Completed Missed primary

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 10 sources stand behind the page.

FieldValueCited text
Known as Na-GST-1 ClinicalTrials.gov intervention name — accepted as the source's own label NCT01385189 ↗
7

NCT02143518 ↗

NCT02839161 ↗

NCT02126462 ↗

NCT02476773 ↗

NCT03172975 ↗

NCT01261130 ↗

NCT03373214 ↗
Known as N americanus glutathione S-transferase-1 “Necator americanus aspartic protease-1 (Na-APR-1) and N americanus glutathione S-transferase-1 (Na-GST-1) are involved in the digestion and detoxification of haemoglobin in the...” PMID 32926834 ↗ Sep 2020
Known as Necator americanus Glutathione-S-Transferase-1 “Necator americanus Glutathione-S-Transferase-1 (Na-GST-1) plays a role in the digestion of host hemoglobin by adult N. americanus hookworms.” PMID 28464026 ↗ May 2017
Modality Protein / enzyme biologic “The Na-GST-1 vaccine formulations to be tested in this study consist of the 24 kDa recombinant protein Na-GST-1 adsorbed to Alhydrogel® either with or without the addition of GLA-AF.” NCT01261130 ↗
Route Intramuscular “Vaccinations were administered via intramuscular injection on days 0, 56, and 112.” PMID 28464026 ↗ May 2017