drugset / Trial / NCT03373214
Na-GST-1/Alhydrogel With or Without CpG 10104 in Gabonese Adults
Phase 1
Completed
24 enrolled
Baylor College of Medicine
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · collabAmsterdam Institute for Global Health and Development · collabCentre de Recherche Médicale de Lambaréné · collabGeorge Washington University · collabLeiden University Medical Center · collab
RandomizedParallel-groupQuadruple-blindPrevention
Summary
Na-GST-1 is a protein expressed during the adult stage of the Necator americanus hookworm life cycle that is thought to play a role in the parasite's degradation of host hemoglobin for use as an energy source. Vaccination with recombinant Na-GST-1 has protected dogs and hamsters from infection in challenge studies. This study will evaluate the safety and immunogenicity of administering Na-GST-1 with or without the CpG 10104 immunostimulant to healthy Gabonese adults living in an area of endemic hookworm infection.
Timeline
- Start
- 2018-02-01
- Primary completion
- 2019-02-28
- Completion
- 2019-03-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Na-GST-1 | Protein / enzyme biologic | 30 ug | Intramuscular |
| Subject | Na-GST-1 | Protein / enzyme biologic | 100 ug | Intramuscular |
| Subject | agatolimod | Oligonucleotide (other) | 500 ug | Intramuscular |