Drugs / LY2584702
last change Jan 2014 re-read 3 minutes ago

LY2584702

also known as LY2584702 tosylate

Small molecule targets RPS6KB1 via inhibition

Developed for
cancer · cancer of unknown primary site · metastatic neoplasm · neuroendocrine neoplasm · non-small cell lung carcinoma · renal cell carcinoma
Investigated by
Eli Lilly and Company

Trials 4

2009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1 NCT01372085 Jun → Sep 2011 — Eli Lilly and Company Completed No outcome recorded
Phase 1 NCT01241461 Nov 2010 → Nov 2011 cancer Eli Lilly and Company Completed No outcome recorded
Phase 1 NCT01115803 Mar 2010 → Jun 2011 metastatic neoplasm, neuroendocrine neoplasm, non-small cell lung carcinoma, renal cell carcinoma Eli Lilly and Company Terminated No outcome recorded
Phase 1 NCT01394003 Nov 2008 → Apr 2011 cancer of unknown primary site Eli Lilly and Company Terminated No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 7 sources stand behind the page.

FieldValueCited text
Known as LY2584702 ClinicalTrials.gov intervention name — accepted as the source's own label NCT01241461 ↗
3

NCT01372085 ↗

NCT01394003 ↗

NCT01115803 ↗

Known as LY2584702 tosylate “BACKGROUND: LY2584702 tosylate (hereafter referred to as LY2584702) is a potent, highly selective adenosine triphosphate (ATP) competitive inhibitor against p70 S6 kinase, a...” PMID 24440085 ↗ Jan 2014
1

“LY2584702 tosylate (hereafter referred to as LY2584702) is an oral, selective ATP competitive inhibitor of p70 S6 kinase.” PMID 24456794 ↗ Jan 2014

Action Inhibit “selective ATP competitive inhibitor of p70 S6 kinase” PMID 24456794 ↗ Jan 2014
1

“Ribosomal protein S6 kinase 1 inhibitor” CHEMBL3545076 ↗

Modality Small molecule — CHEMBL3545076 ↗
Route Oral “administered orally” NCT01115803 ↗
Target RPS6KB1 “Ribosomal protein S6 kinase 1 inhibitor” CHEMBL3545076 ↗