Drugs / LY2940094
last change Aug 2026 re-read 3 minutes ago

LY2940094

also known as BTRX-246040 · J3.309.394B

Small molecule targets OPRL1 via inhibition

Developed for
major depressive disorder · alcohol dependence · anxiety · movement disorder · Parkinson disease
Investigated by
BlackThorn Therapeutics, Inc. · Mclean Hospital · National Institute of Mental Health (NIMH)

Trials 7

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 12 trials
Phase 1 NCT01404091 Jul → Nov 2011 depressive disorder BlackThorn Therapeutics, Inc. Completed No outcome recorded
Phase 1 NCT01263236 Dec 2010 → Sep 2011 major depressive disorder BlackThorn Therapeutics, Inc. Completed No outcome recorded
Phase 25 trials · 1 missed
Phase 2 NCT06786637 Jun 2025 → Jan 2026 anxiety, major depressive disorder Mclean Hospital Withdrawn No outcome recorded
Phase 2 NCT03608371 Aug 2018 → Apr 2019 Parkinson disease, movement disorder BlackThorn Therapeutics, Inc. Completed No outcome recorded
Phase 2 NCT03193398 Jun 2017 → Nov 2018 major depressive disorder BlackThorn Therapeutics, Inc. Completed Missed primary
Phase 2 NCT01798303 Jul 2013 → Jun 2014 alcohol dependence BlackThorn Therapeutics, Inc. Completed No outcome recorded
Phase 2 NCT01724112 Nov 2012 → Mar 2014 major depressive disorder BlackThorn Therapeutics, Inc. Completed No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 8 sources stand behind the page.

FieldValueCited text
Known as LY-2940094 ClinicalTrials.gov intervention name — accepted as the source's own label NCT06786637 ↗
4

NCT01404091 ↗

NCT01263236 ↗

NCT01798303 ↗

NCT01724112 ↗

Known as BTRX-246040 ClinicalTrials.gov intervention name — accepted as the source's own label NCT03193398 ↗
1

NCT03608371 ↗

Known as J3.309.394B ChEMBL registry synonym — accepted as the source's own label CHEMBL3304244 ↗
Action Inhibit “Nociceptin receptor antagonist” CHEMBL3304244 ↗
Modality Small molecule — CHEMBL3304244 ↗
Route Oral “Administered orally” NCT01263236 ↗
Target OPRL1 “Nociceptin receptor antagonist” CHEMBL3304244 ↗