Investigating the Protective Impact of LY-2940094 on Stress-induced Depression- and Anxiety-related Phenotypes in Humans

Summary

This project will integrate pharmacological and psychophysiological methodology to mechanistically investigate, in humans, the role of N/OFQ in laboratory phenotypes of both disorders. Specifically, a N/OFQ receptor (NOPR) antagonist will be used to test the hypothesis that NOPR blockage will have antidepressant-like effects (potentiate reward processing); in addition, this study will also evaluate a key anxiety phenotype (fear learning). Finally, the impact of recent life stress on these processes will be assessed. Results will demonstrate the specificity of NOPR blockage on depressive phenotypes or suggest a common pathway for emotional disorders and will confirm a modulatory role of life stress.

Timeline

Start

2025-06

Primary completion

2026-01

Completion

2026-08

Outcome

Outcome not reported

Stopped: “PI transferred to a different research institution and local institution would not allow to continue the study. Transfer of the study to a different study site not possible because of unique requirements of resources (e.g., nociceptin anatagonist)”

Drugs

Indications