Drugs / LY404039
last change Feb 2026 re-read 9 days ago

LY404039

also known as Pomaglumetad

Small molecule targets GRM2, GRM3 via activation

Developed for
methamphetamine dependence
Investigated by
Denovo Biopharma LLC · National Institute on Drug Abuse (NIDA) · University of California, Los Angeles

Trials 2

201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1 NCT03106571 Aug 2017 → Jul 2020 methamphetamine dependence University of California, Los Angeles Terminated No outcome recorded Stop: Enrollment
Phase 1 NCT01637142 Jul 2012 — Denovo Biopharma LLC Completed No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 3 sources stand behind the page.

FieldValueCited text
Known as LY404039 ClinicalTrials.gov intervention name — accepted as the source's own label NCT01637142 ↗
Known as Pomaglumetad ClinicalTrials.gov intervention name — accepted as the source's own label NCT03106571 ↗
Action Activate “Metabotropic glutamate receptor 3 agonist” CHEMBL375611 ↗
1

“Metabotropic glutamate receptor 2 agonist” CHEMBL375611 ↗

Modality Small molecule — CHEMBL375611 ↗
Route Intravenous “Administered IV.” NCT01637142 ↗
Target GRM2 “Metabotropic glutamate receptor 2 agonist” CHEMBL375611 ↗
Target GRM3 “Metabotropic glutamate receptor 3 agonist” CHEMBL375611 ↗