Drugs / sevelamer

Regulatory milestones approvals, filings & regulatory actions · 3 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansion US (FDA) RENVELA 2016-11-25 fda.gov
Approved EU (EMA) Renvela 2009-06-09 europa.eu
Approved US (FDA) RENVELA 2007-10-19 fda.gov

Trials 21 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT01308242 Mar 2011 → Feb 2014 chronic kidney disease Milton S. Hershey Medical Center Completed No outcome recorded
Phase 14 trials
Phase 1 NCT04299633 Jun → Aug 2020 Akebia Therapeutics Completed No outcome recorded
Phase 1 NCT02346890 Apr 2013 Ardelyx Completed No outcome recorded
Phase 1 NCT00925704 Jun → Jul 2009 Shire Completed No outcome recorded
Phase 1 NCT00967629 Jun 2009 → Feb 2010 diabetic kidney disease Icahn School of Medicine at Mount Sinai Completed No outcome recorded
Phase 24 trials
Phase 2 NCT01574326 May 2012 → Jun 2015 chronic kidney disease, hyperphosphatemia Genzyme, a Sanofi Company Completed No outcome recorded
Phase 2 NCT01493050 Feb 2012 → Dec 2013 diabetic kidney disease Gary Striker Completed No outcome recorded
Phase 2 NCT01543958 Nov 2011 → Sep 2012 HIV infectious disease Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections Completed No outcome recorded
Phase 2 NCT01231438 Oct 2010 → Mar 2011 kidney failure Helse Stavanger HF Completed No outcome recorded
Phase 37 trials
Phase 3 NCT03596749 Sep 2018 → May 2019 chronic kidney disease Fan Fan Hou Unknown No outcome recorded
Phase 3 NCT02332811 Oct 2013 → Jul 2014 chronic renal failure syndrome Genzyme, a Sanofi Company Completed No outcome recorded
Phase 3 NCT01220843 Oct 2010 → Apr 2013 chronic renal failure syndrome Centre Hospitalier Universitaire, Amiens Completed No outcome recorded
Phase 3 NCT01191255 Oct 2010 → Jan 2013 hyperphosphatemia, kidney failure Keryx Biopharmaceuticals Completed No outcome recorded
Phase 3 NCT01736150 Mar → Sep 2010 chronic kidney disease Genzyme, a Sanofi Company Completed No outcome recorded
Phase 3 NCT00681941 Jan 2006 → Jan 2007 chronic kidney disease, hyperphosphatemia Genzyme, a Sanofi Company Completed No outcome recorded
Phase 3 NCT00268957 Jan 2006 → Mar 2007 chronic renal failure syndrome, end stage renal failure Genzyme, a Sanofi Company Completed No outcome recorded
Phase 43 trials
Phase 4 NCT04485039 Jun → Dec 2022 smallpox SIGA Technologies Completed No outcome recorded
Phase 4 NCT03988920 Jun 2019 → Jun 2021 end stage renal failure, hyperphosphatemia Ardelyx Completed No outcome recorded
Phase 4 NCT01277497 Jan 2011 → Jan 2016 chronic kidney disease Albany College of Pharmacy and Health Sciences Terminated No outcome recorded
Phase not applicable2 trials
NCT02644486 Jan 2016 → Feb 2018 glomerular disorder Zhi-Hong Liu, M.D. Terminated No outcome recorded
NCT00999037 Oct 2009 → Jun 2015 secondary hyperparathyroidism of renal origin University of California, Los Angeles Completed No outcome recorded
Also used as a comparator or background therapy in 16 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT02965053 Background Dec 2016 → Aug 2018 hyperphosphatemia Chugai Pharmaceutical Completed No outcome recorded
Phase 23 trials
Phase 2 NCT06664125 Comparator Dec 2024 → Jun 2025 overdue hyperphosphatemia Jemincare Recruiting No outcome recorded
Phase 2 NCT05764590 Comparator Feb → Aug 2023 chronic kidney disease, hyperphosphatemia Alebund Pharmaceuticals Completed No outcome recorded
Phase 2 NCT04551300 Comparator Oct 2020 → Jun 2022 hyperphosphatemia Shanghai Alebund Pharmaceuticals Limited Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT03824587 Background Feb → Jul 2019 hyperphosphatemia Ardelyx Completed No outcome recorded
Phase 39 trials
Phase 3 NCT07030595 Comparator Jun 2023 → Oct 2024 end stage renal failure, hyperphosphatemia Alebund Pharmaceuticals Completed No outcome recorded
Phase 3 NCT03984760 Comparator Jun 2019 → Feb 2021 end stage renal failure, hyperphosphatemia Panion & BF Biotech Inc. Completed No outcome recorded
Phase 3 NCT04456803 Comparator May 2019 → Sep 2022 end stage renal failure, hyperphosphatemia Sinomune Pharmaceutical Co., Ltd Completed No outcome recorded
Phase 3 NCT03644264 Comparator Aug 2018 → Aug 2020 chronic kidney disease, hyperphosphatemia Vifor Fresenius Medical Care Renal Pharma Completed No outcome recorded
Phase 3 NCT03427125 Comparator Jan 2018 → Nov 2019 hyperphosphatemia Ardelyx Completed No outcome recorded
Phase 41 trial
Phase 4 NCT01427907 Comparator Sep 2011 → Jul 2012 chronic kidney disease Fresenius Medical Care North America Completed No outcome recorded
Phase not applicable1 trial
NCT00785629 Comparator Feb 2009 → Jul 2011 chronic kidney disease Denver Nephrologists, P.C. Completed No outcome recorded

Evidence & citations 10 cited values

Every value below carries the sentence it was read from. 39 sources stand behind the page.

FieldValueCited text
Known as sevelamer “Sucroferric oxyhydroxide (SFOH) is a non-calcium, iron-based phosphate binder that demonstrated sustained serum phosphorus (sP) control, good tolerability, and lower pill...” PMID 29656600 Apr 2018
Known as GT-335-012 ChEMBL registry synonym — accepted as the source's own label CHEMBL5314349
Known as Renvela “Multi-Center Study of the Effect of Sevelamer Carbonate (Renvela®) on Metabolic/Inflammatory/ROS in Diabetics With Nephropathy” NCT01493050
7

“Lanthanum Carbonate (FOSRENOL®) or Sevelamer Carbonate (RENVELA®)” NCT00925704

“Drug: Sevelamer carbonate (Renvela®)” NCT00681941

“Sevelamer carbonate (Renvela®)” NCT00268957

“Sevelamer carbonate (Renvela®)” NCT07030595

NCT01231438

NCT02965053

NCT02346890

Known as Sevelamer anhydrous ChEMBL registry synonym — accepted as the source's own label CHEMBL5314349
Known as Sevelamer carbonate sevelamer carbonateNCT03824587
33

NCT01464190

NCT05764590

NCT07030595

NCT01191762

NCT03984760

NCT00999037

NCT04485039

NCT00925704

NCT06664125

NCT04456803

NCT01543958

NCT02644486

NCT01277497

NCT03427125

NCT01324128

NCT03596749

NCT03988920

NCT01427907

NCT03644264

NCT00268957

NCT00785629

NCT00681941

NCT01574326

NCT00833768

NCT04551300

NCT04299633

NCT02332811

NCT01220843

NCT01308242

NCT01493050

NCT00967629

NCT01736150

NCT01191255

Known as Sevelamer carbonate winthrop (previously sevelamer carbonate zentiva) ChEMBL registry synonym — accepted as the source's own label CHEMBL5314349
Known as Sevelamer carbonate zentiva ChEMBL registry synonym — accepted as the source's own label CHEMBL5314349
Known as Sevelamero ChEMBL registry synonym — accepted as the source's own label CHEMBL5314349
Modality Other / unclassified “A double-blind trial of the intestinal phosphate binder sevelamer carbonate will be employed” NCT01191762
Route Oral “800mg tablets to be taken orally with meals three times per day” NCT00833768