Drugs / Tibolone
Tibolone
Trials 11 · a red edge is where a trial was stopped
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 21 trial | ||||||
| Phase 2 | NCT00165204 | Apr 2004 → Mar 2006 | breast cancer, postmenopausal osteoporosis, premature menopause | Dana-Farber Cancer Institute | Completed | No outcome recorded |
| Phase 33 trials | ||||||
| Phase 3 | NCT00299364 | Sep 2004 → May 2005 | — | Schaper & Bruemmer GmbH & Co KG | Completed | No outcome recorded |
| Phase 3 | NCT00413764 | Mar 2004 → Nov 2005 | sexual disorder | Organon and Co | Completed | No outcome recorded |
| Phase 3 | NCT00745108 | Oct 2001 → Jul 2005 | — | Organon and Co | Completed | No outcome recorded |
| Phase 45 trials | ||||||
| Phase 4 | NCT06117969 | Dec 2023 → Jun 2024 | sleep disorder | Peking Union Medical College Hospital | Unknown | No outcome recorded |
| Phase 4 | NCT01822288 | Nov 2012 → Jul 2021 | — | Far Eastern Memorial Hospital | Completed | No outcome recorded |
| Phase 4 | NCT01368068 | Jul 2012 | — | The Alfred | Terminated | No outcome recorded |
| Phase 4 | NCT00294463 | Feb 2003 → Mar 2005 | osteoporosis | Erasmus Medical Center | Completed | No outcome recorded |
| Phase 4 | NCT00431431 | Jul 2000 → Feb 2005 | — | Organon and Co | Completed | No outcome recorded |
| Phase not applicable2 trials | ||||||
| — | NCT01543399 | Mar 2012 → Feb 2015 | — | Selmo Geber | Completed | No outcome recorded |
| — | NCT01679795 | Feb 2012 → Feb 2015 | — | Federal University of Minas Gerais | Completed | No outcome recorded |
Also used as a comparator or background therapy in 11 trials
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 11 trial | ||||||
| Phase 1 | NCT01239888 Comparator | Jan → Nov 2012 | major depressive disorder | The Alfred | Unknown | No outcome recorded |
| Phase 33 trials | ||||||
| Phase 3 | NCT00725374 Comparator | Dec 2002 → Apr 2005 | breast cancer | Organon and Co | Completed | No outcome recorded |
| Phase 3 | NCT00408863 Comparator | May 2002 → Oct 2007 | breast cancer | Organon and Co | Completed | No outcome recorded |
| Phase 3 | NCT00519857 Comparator | Jul 2001 → Aug 2006 | osteoporosis | Organon and Co | Completed | No outcome recorded |
| Phase 47 trials | ||||||
| Phase 4 | NCT02393482 Comparator | Jun → Dec 2021 | amenorrhea, endometriosis | University of Cagliari | Unknown | No outcome recorded |
| Phase 4 | NCT01470092 Comparator | Jul 2012 → Dec 2017 | — | The Alfred | Completed | No outcome recorded |
| Phase 4 | NCT00654524 Background | Mar 2008 → Dec 2009 | endometriosis | Zhejiang University | Unknown | No outcome recorded |
| Phase 4 | NCT00472004 Comparator | Feb 2006 → Dec 2009 | — | Wyeth is now a wholly owned subsidiary of Pfizer | Completed | No outcome recorded |
| Phase 4 | NCT00145522 Comparator | Nov 2005 → Mar 2009 | — | Solvay Pharmaceuticals | Completed | No outcome recorded |
| Phase 4 | NCT00809068 Comparator | Aug 2005 → Aug 2009 | — | Keogh Institute for Medical Research | Completed | No outcome recorded |
| Phase 4 | NCT00431093 Comparator | Nov 2002 → Mar 2005 | — | Organon and Co | Completed | No outcome recorded |
Evidence & citations 9 cited values
Every value below carries the sentence it was read from. 24 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Tibolone | ClinicalTrials.gov intervention name — accepted as the source's own label NCT01822288 ↗ |
| Known as | Livial | “Tibolone-group (2.5 mg tibolone (Livial, N.V. Organon, Oss, The Netherlands) administered orally every day, starting 21 days prior to surgery)” NCT00294463 ↗1“Livial 1.25-2.5mg p.o. q.d.” NCT00654524 ↗ |
| Known as | Livial (tibolone) | “Livial (tibolone)” NCT01239888 ↗ |
| Known as | NSC-759898 | ChEMBL registry synonym — accepted as the source's own label CHEMBL2103774 ↗ |
| Known as | Org OD-14 | “2 years treatment with tibolone (1.25 mg Org OD-14)” NCT00431431 ↗ |
| Known as | Tibolona | ChEMBL registry synonym — accepted as the source's own label CHEMBL2103774 ↗ |
| Action | Activate | “The mechanism of tibolone on HDL cholesterol has been suggested to result from an acceleration of the catabolism of HDL by stimulation of hepatic lipase with no effect on...” NCT00809068 ↗ |
| Modality | Other / unclassified | “Tibolone, a synthetic steroid, is effective in reducing these symptoms in healthy post-menopausal women” PMID 22030384 ↗ Oct 2011 |
| Route | Oral | “2.5 mg tibolone (Livial, N.V. Organon, Oss, The Netherlands) administered orally every day” NCT00294463 ↗ |