Drugs / Rimiducid

Trials 18

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 112 trials
Phase 1 NCT03696784 Mar 2019 → Aug 2025 overdue B-cell non-Hodgkin lymphoma, immunoproliferative disorder, lymphatic system disorder UNC Lineberger Comprehensive Cancer Center Active not recruiting No outcome recorded
Phase 1 NCT03459170 Feb 2018 → Sep 2022 overdue hematopoietic and lymphoid cell neoplasm Bellicum Pharmaceuticals Active not recruiting No outcome recorded
Phase 1 NCT02744287 Nov 2016 → Mar 2023 castration-resistant prostate carcinoma, metastatic prostate carcinoma Regeneron Pharmaceuticals Terminated No outcome recorded
Phase 1 NCT02477878 Jul 2016 → Jan 2020 overdue leukemia, myelodysplastic syndrome, plasma cell myeloma Bellicum Pharmaceuticals Active not recruiting No outcome recorded
Phase 1 NCT02487459 Jul 2016 → Jun 2017 hematopoietic and lymphoid cell neoplasm Bellicum Pharmaceuticals Withdrawn No outcome recorded
Phase 1 NCT02786485 May 2016 → Dec 2018 leukemia, myelodysplastic syndrome, plasma cell myeloma Bellicum Pharmaceuticals Withdrawn No outcome recorded
Phase 1 NCT02231710 Feb → Sep 2015 bone marrow failure syndrome, hemoglobinopathy, hemophagocytic syndrome, immunodeficiency disease +1 Bellicum Pharmaceuticals Terminated No outcome recorded Stop: Enrollment
Phase 1 NCT02107963 Feb 2014 → Aug 2016 melanoma, neuroblastoma, osteosarcoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 1 NCT03016377 Mar 2012 → Sep 2025 overdue acute lymphoblastic leukemia, immunoproliferative disorder UNC Lineberger Comprehensive Cancer Center Active not recruiting No outcome recorded
Phase 1 NCT01494103 Nov 2011 → May 2029 expected Epstein-Barr virus infection, X-linked lymphoproliferative syndrome, acute lymphoblastic leukemia, acute myeloid leukemia +3 Baylor College of Medicine Active not recruiting No outcome recorded
Phase 1/26 trials
Phase 1/2 NCT02849886 Apr 2019 → Dec 2021 graft versus host disease, hematopoietic and lymphoid cell neoplasm Centre Hospitalier Universitaire de Besancon Terminated No outcome recorded Stop: Enrollment
Phase 1/2 NCT02743611 Apr 2017 → Jul 2019 acute myeloid leukemia, myelodysplastic syndrome, uveal melanoma Bellicum Pharmaceuticals Terminated No outcome recorded
Phase 1/2 NCT02065869 Apr 2014 → Jun 2020 Diamond-Blackfan anemia, Fanconi anemia, acute lymphoblastic leukemia, childhood acute myeloid leukemia +5 Bellicum Pharmaceuticals Terminated No outcome recorded Stop: Business
Phase 1/2 NCT03301168 Apr 2014 → May 2021 overdue acute lymphoblastic leukemia, aplastic anemia, childhood acute myeloid leukemia, hemoglobinopathy +3 Bellicum Pharmaceuticals Active not recruiting No outcome recorded
Phase 1/2 NCT01875237 Dec 2013 → Mar 2017 leukemia, myeloproliferative neoplasm, plasma cell myeloma M.D. Anderson Cancer Center Terminated No outcome recorded
Phase 1/2 NCT01744223 Mar 2013 → Oct 2019 overdue acute lymphoblastic leukemia, acute myeloid leukemia, myelodysplastic syndrome Bellicum Pharmaceuticals Active not recruiting No outcome recorded
Comparator or background therapy21 trials
Phase 1 NCT07553390 Background Oct 2026 → Mar 2036 expected breast cancer M.D. Anderson Cancer Center Not yet recruiting No outcome recorded
Phase 1 NCT06984341 Background Jun 2026 → Nov 2033 expected systemic lupus erythematosus Genentech, Inc. Not yet recruiting No outcome recorded
Phase 1 NCT06014762 Background Apr 2024 → Mar 2029 expected high grade B-cell lymphoma, primary mediastinal large B-cell lymphoma Poseida Therapeutics, Inc. Active not recruiting No outcome recorded
Phase 1 NCT06066424 Background Oct 2023 → Apr 2038 expected cancer M.D. Anderson Cancer Center Recruiting No outcome recorded
Phase 1 NCT04960579 Background May 2022 → Mar 2029 expected plasma cell myeloma Poseida Therapeutics, Inc. Active not recruiting No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 41 sources stand behind the page.

FieldValueCited text
Known as Rimiducid “chemical inducer of dimerization (CID; AP1903/Rimiducid)” PMID 25977584 ↗ May 2015
27

“Drug: rimiducid” NCT03699475 ↗

NCT03639844 ↗

NCT03807063 ↗

NCT02477878 ↗

NCT04960579 ↗

NCT02743611 ↗

NCT05239143 ↗

NCT03301168 ↗

NCT07553390 ↗

NCT07509008 ↗

Show 17 more sources

Known as AP1903 “Rimiducid/AP1903: Dimerizer drug administered to subjects who develop Grade III-IV acute GVHD, Grade II gut/liver acute GVDH or Grade I/II skin-only acute GvHD which is...” NCT02065869 ↗
16

“A single dose of a small-molecule drug (AP1903) eliminated more than 90 % of the modified T cells within 30 min after administration and symptoms resolved without recurrence.” PMID 26072403 ↗ 2015

“the safety of Rimiducid (AP1903) on day 7 to prevent GVHD” NCT02231710 ↗

“Rimiducid (AP1903)” NCT07598955 ↗

“Rimiducid (AP1903)” NCT07164469 ↗

“Rimiducid (AP1903)” NCT07509008 ↗

NCT02487459 ↗

NCT02849886 ↗

NCT02792114 ↗

NCT03696784 ↗

NCT01494103 ↗

Show 6 more sources

Known as AP1903 Dimerizer Drug “AP1903 Dimerizer Drug” NCT01494103 ↗
Action Activate “The drug (AP1903) that will be used to "activate" the iCasp9” NCT00710892 ↗
Modality Small molecule “A single dose of a small-molecule drug (AP1903)” PMID 26072403 ↗ 2015
Route Intravenous “This drug will be given as a 2-hour intravenous infusion.” NCT00710892 ↗