Drugs / tasimelteon

Regulatory milestones approvals, filings & regulatory actions · 3 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansion US (FDA) HETLIOZ 2020-12-01 fda.gov
Approved EU (EMA) Hetlioz 2015-07-03 europa.eu
Approved US (FDA) HETLIOZ 2014-01-31 fda.gov

Trials 26 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT05922995 Sep → Dec 2023 REM sleep behavior disorder Brigham and Women's Hospital Terminated No outcome recorded
Phase 19 trials
Phase 1 NCT06323655 Jul → Aug 2018 Vanda Pharmaceuticals Completed No outcome recorded
Phase 1 NCT02776215 Oct 2016 → Dec 2017 Smith-Magenis syndrome, autism spectrum disorder, non-24-hour sleep-wake syndrome Vanda Pharmaceuticals Completed No outcome recorded
Phase 1 NCT01637636 Jun → Aug 2012 Vanda Pharmaceuticals Completed No outcome recorded
Phase 1 NCT01578057 Apr → Jun 2012 Vanda Pharmaceuticals Completed No outcome recorded
Phase 1 NCT01526746 Feb → Jun 2012 impaired renal function disease Vanda Pharmaceuticals Completed No outcome recorded
Phase 1 NCT01540500 Feb → Mar 2012 Vanda Pharmaceuticals Completed No outcome recorded
Phase 1 NCT01477619 Nov 2011 → Jan 2012 Vanda Pharmaceuticals Completed No outcome recorded
Phase 1 NCT01402076 Aug 2011 Vanda Pharmaceuticals Completed No outcome recorded
Phase 1 NCT01271387 Jan → Aug 2011 Vanda Pharmaceuticals Completed No outcome recorded
Phase 22 trials
Phase 2 NCT03291041 Jul 2016 → Nov 2017 circadian rhythm sleep disorder, jet lag type Vanda Pharmaceuticals Completed No outcome recorded
Phase 2 NCT00490945 Jul 2004 → Mar 2005 circadian rhythm sleep disorder Vanda Pharmaceuticals Completed No outcome recorded
Phase 2/32 trials
Phase 2/3 NCT02231008 Sep 2015 → Nov 2018 Smith-Magenis syndrome, circadian rhythm sleep disorder Vanda Pharmaceuticals Completed No outcome recorded
Phase 2/3 NCT01428661 Sep 2011 → Jan 2013 major depressive disorder Vanda Pharmaceuticals Completed No outcome recorded
Phase 311 trials
Phase 3 NCT06953869 Apr 2025 → Nov 2027 expected insomnia Vanda Pharmaceuticals Recruiting No outcome recorded
Phase 3 NCT06701396 Oct 2024 → Jun 2025 overdue circadian rhythm sleep disorder, delayed sleep phase type Vanda Pharmaceuticals Recruiting No outcome recorded
Phase 3 NCT05361707 Jul 2021 → Jul 2025 autism spectrum disorder, sleep disorder Vanda Pharmaceuticals Unknown No outcome recorded
Phase 3 NCT04652882 Dec 2020 → Jun 2026 overdue circadian rhythm sleep disorder Vanda Pharmaceuticals Recruiting No outcome recorded
Phase 3 NCT03373201 Oct 2017 → Mar 2018 circadian rhythm sleep disorder, jet lag type Vanda Pharmaceuticals Completed No outcome recorded
Phase 3 NCT01429116 Oct 2011 → Jan 2015 non-24-hour sleep-wake syndrome Vanda Pharmaceuticals Completed No outcome recorded
Phase 3 NCT01430754 Sep 2011 → Dec 2012 non-24-hour sleep-wake syndrome Vanda Pharmaceuticals Completed No outcome recorded
Phase 3 NCT01218789 Oct 2010 → Dec 2024 non-24-hour sleep-wake syndrome Vanda Pharmaceuticals Unknown No outcome recorded
Phase 3 NCT01163032 Aug 2010 → Nov 2012 non-24-hour sleep-wake syndrome Vanda Pharmaceuticals Completed No outcome recorded
Phase 3 NCT00548340 Nov 2007 → Feb 2008 insomnia Vanda Pharmaceuticals Completed No outcome recorded
Phase 41 trial
Phase 4 NCT02130999 May 2014 non-24-hour sleep-wake syndrome Vanda Pharmaceuticals Completed No outcome recorded

Evidence & citations 8 cited values

Every value below carries the sentence it was read from. 28 sources stand behind the page.

FieldValueCited text
Known as tasimelteon “Melatonin agonist tasimelteon (VEC-162) for transient insomnia after sleep-time shift: two randomised controlled multicentre trials.” PMID 19054552 Dec 2008
24

“VEC-162 (tasimelteon) 20 mg capsules PO daily for five weeks” NCT00548340

NCT01540500

NCT01578057

NCT01163032

NCT01271387

NCT03291041

NCT06953869

NCT01402076

NCT01428661

NCT05922995

NCT01218789

NCT04652882

NCT01637636

NCT03373201

NCT02231008

NCT02130999

NCT02776215

NCT05361707

NCT06323655

NCT01526746

NCT01477619

NCT01430754

NCT01429116

NCT06701396

Known as BMS-214,778 ChEMBL registry synonym — accepted as the source's own label CHEMBL2103822
Known as HETLIOZ “Efficacy of Tasimelteon (HETLIOZ®) in the Treatment of Jet Lag Disorder” PMID 32754110 Jul 2020
Known as Hetlioz lq ChEMBL registry synonym — accepted as the source's own label CHEMBL2103822
Known as VEC-162 “Melatonin agonist tasimelteon (VEC-162) for transient insomnia after sleep-time shift: two randomised controlled multicentre trials.” PMID 19054552 Dec 2008
1

NCT00548340

Action Activate “the melatonin agonist tasimelteon (VEC-162) for treatment of transient insomnia associated with shifted sleep and wake time.” PMID 19054552 Dec 2008
Modality Small molecule CHEMBL2103822
Route Oral “20 mg taken orally 30 minutes prior to bedtime.” NCT00291187