drugset / Trial / NCT01402076
A Study to Assess the Effect Tasimelteon on the Cytochrome P450 3A4 and 2C8 Enzymes in Healthy Subjects
Non-randomizedParallel-groupOpen-labelBasic science
Summary
The purpose of this research study is to understand whether there is any difference in the amount of midazolam (including its breakdown product) in the blood when midazolam is given with tasimelteon, and whether there is any difference in the amount of rosiglitazone in the blood when rosiglitazone is given with tasimelteon.
Timeline
- Start
- 2011-08
- Primary completion
- 2011-08
- Completion
- 2011-08
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Midazolam | Small molecule | 10 mg | — |
| Subject | Rosiglitazone | Small molecule | 4 mg | — |
| Subject | tasimelteon | Small molecule | 20 mg | — |
Indications
No indication recorded.