Drugs / Zilovertamab vedotin

Trials 10 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT03833180 Mar 2019 → Dec 2023 B-cell chronic lymphocytic leukemia, Burkitt lymphoma, Richter transformation, T-cell non-Hodgkin lymphoma +6 VelosBio Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) Completed No outcome recorded
Phase 1/22 trials
Phase 1/2 NCT06395103 Aug 2024 → Mar 2029 expected B-cell acute lymphoblastic leukemia, Burkitt lymphoma, Ewing sarcoma, diffuse large B-cell lymphoma +1 Merck Sharp & Dohme LLC Recruiting No outcome recorded
Phase 1/2 NCT05562830 Nov 2022 → Feb 2029 expected urothelial carcinoma Merck Sharp & Dohme LLC Recruiting No outcome recorded
Phase 25 trials
Phase 2 NCT06890884 Apr 2025 → Dec 2027 expected diffuse large B-cell lymphoma Merck Sharp & Dohme LLC Recruiting No outcome recorded
Phase 2 NCT05458297 Jul 2022 → May 2029 expected B-cell chronic lymphocytic leukemia, Richter transformation, follicular lymphoma, mantle cell lymphoma Merck Sharp & Dohme LLC Active not recruiting No outcome recorded
Phase 2 NCT05406401 Jul 2022 → Apr 2029 expected diffuse large B-cell lymphoma Merck Sharp & Dohme LLC Active not recruiting No outcome recorded
Phase 2 NCT05144841 Jan 2022 → Apr 2026 relapsed/refractory diffuse large B-cell lymphoma Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 2 NCT04504916 Oct 2020 → Jun 2023 estrogen-receptor positive breast cancer, gastric cancer, malignant pancreatic neoplasm, non-small cell lung carcinoma +2 VelosBio Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) Terminated No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT05139017 Jan 2022 → Sep 2027 expected diffuse large B-cell lymphoma Merck Sharp & Dohme LLC Recruiting No outcome recorded
Phase 31 trial
Phase 3 NCT06717347 Jan 2025 → Jul 2029 expected diffuse large B-cell lymphoma Merck Sharp & Dohme LLC Recruiting No outcome recorded

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 11 sources stand behind the page.

FieldValueCited text
Known as Zilovertamab vedotin ClinicalTrials.gov intervention name — accepted as the source's own label NCT06395103
9

NCT05562830

NCT05458297

NCT06717347

NCT06890884

NCT05144841

NCT03833180

NCT05406401

NCT05139017

NCT04504916

Known as MK-2140 “A Study of Zilovertamab Vedotin (MK-2140) (VLS-101) in Participants With Hematologic Malignancies (MK-2140-001)” NCT03833180
Known as VLS-101 “A Study of Zilovertamab Vedotin (MK-2140) (VLS-101) in Participants With Hematologic Malignancies (MK-2140-001)” NCT03833180
Route Intravenous “Zilovertamab vedotin administered via IV infusion per Schedule 1, 2, or 3 according to participant allocation.” NCT03833180
Target ROR1 “Zilovertamab Vedotin Targeting of ROR1 as Therapy for Lymphoid Cancers.” PMID 38319241 Oct 2021