Drugs / N-SULFOGLUCOSAMINE SULFOHYDROLASE RECOMBINANT
N-SULFOGLUCOSAMINE SULFOHYDROLASE RECOMBINANT
Trials 1
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 1/21 trial | ||||||
| Phase 1/2 | NCT01155778 | Jun 2010 → Sep 2012 | mucopolysaccharidosis | Shire | Completed | No outcome recorded |
| Comparator or background therapy1 trial | ||||||
| Phase 2 | NCT02350816 Comparator | Apr 2015 → Apr 2019 | mucopolysaccharidosis type 3A | Shire | Terminated | No outcome recorded |
Evidence & citations 12 cited values
Every value below carries the sentence it was read from. 4 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | N-SULFOGLUCOSAMINE SULFOHYDROLASE RECOMBINANT | ChEMBL registry synonym — accepted as the source's own label CHEMBL4297976 ↗ |
| Known as | Amidase, sulfoglucosamine sulf- | ChEMBL registry synonym — accepted as the source's own label CHEMBL4297976 ↗ |
| Known as | HGT-1410 | ClinicalTrials.gov intervention name — accepted as the source's own label NCT02350816 ↗ |
| Known as | N-sulfoglucosamine sulfohydrolase | ChEMBL registry synonym — accepted as the source's own label CHEMBL4297976 ↗ |
| Known as | recombinant human heparan-N-sulfatase | “Recombinant human heparan N-sulfatase (rhHNS)” NCT01155778 ↗ |
| Known as | rhHNS | “Recombinant human heparan N-sulfatase (rhHNS)” NCT01155778 ↗ |
| Known as | Shp-610 | ChEMBL registry synonym — accepted as the source's own label CHEMBL4297976 ↗ |
| Known as | Sulfamidase recombinant | ChEMBL registry synonym — accepted as the source's own label CHEMBL4297976 ↗ |
| Known as | Sulfoglucosamine sulfamidase | ChEMBL registry synonym — accepted as the source's own label CHEMBL4297976 ↗ |
| Known as | Sulphamidase | ChEMBL registry synonym — accepted as the source's own label CHEMBL4297976 ↗ |
| Modality | Protein / enzyme biologic | “Shire Human Genetic Therapies (Shire HGT) is developing a sulfamidase enzyme replacement therapy (ERT)rhHNS for patients with MPS IIIA.” NCT01155778 ↗ |
| Route | Intrathecal | “intrathecal recombinant human heparan-N-sulfatase (rhHNS) administered via intrathecal drug delivery device (IDDD)” PMID 27211612 ↗ May 2016 |