Drugs / Sivelestat
Sivelestat
also known as
Sivelestat sodium · sivelestat sodium hydrate · SSH · EI-546 · Elaspol · LY-544349 · LY-544349 SODIUM HYDRATE · ONO-5046 · +5 more
Small molecule targets ELANE via inhibition
Trials 16 · a red edge is where a trial was stopped
Also used as a comparator or background therapy in 2 trials
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| — | NCT06387823 Comparator | Apr 2024 → Jun 2025 | acute respiratory distress syndrome | Peking Union Medical College Hospital | Unknown | No outcome recorded |
| — | NCT01170845 Comparator | Mar 2007 → Mar 2009 | esophageal cancer | Yokohama City University Medical Center | Completed | No outcome recorded |
Evidence & citations 18 cited values
Every value below carries the sentence it was read from. 23 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | sivelestat | “the neutrophil elastase inhibitor, sivelestat” PMID 23596346 ↗ Apr 2013 |
| Known as | EI-546 | ChEMBL registry synonym — accepted as the source's own label CHEMBL76688 ↗ |
| Known as | Elaspol | ChEMBL registry synonym — accepted as the source's own label CHEMBL76688 ↗ |
| Known as | LY-544349 | ChEMBL registry synonym — accepted as the source's own label CHEMBL76688 ↗ |
| Known as | LY-544349 SODIUM HYDRATE | ChEMBL registry synonym — accepted as the source's own label CHEMBL76688 ↗ |
| Known as | ONO-5046 | ChEMBL registry synonym — accepted as the source's own label CHEMBL76688 ↗ |
| Known as | ONO-5046 SODIUM HYDRATE | ChEMBL registry synonym — accepted as the source's own label CHEMBL76688 ↗ |
| Known as | ONO-5046Na | ClinicalTrials.gov intervention name — accepted as the source's own label NCT00417326 ↗ |
| Known as | Sivelestat sodium | “The total 24-hour dose of Sivelestat sodium (4.8mg/kg) was dissolved with 50 ml normal saline.” NCT06195267 ↗ |
| Known as | sivelestat sodium hydrate | “Postischemic infusion of sivelestat sodium hydrate, a selective neutrophil elastase inhibitor, protects against myocardial stunning in swine.” PMID 20464430 ↗ May 2010 |
| Known as | Sivelestat sodium salt tetrahydrate | ChEMBL registry synonym — accepted as the source's own label CHEMBL76688 ↗ |
| Known as | Sivelestat sodium tetrahydrate | ChEMBL registry synonym — accepted as the source's own label CHEMBL76688 ↗ |
| Known as | sodium N-\[2-\[4-(2,2-dimethylpropionyloxy) phenyl-sulfonylaminobenzoyl\]amino-acetate tetrahydrate\] | “Sivelestat, a specific inhibitor of neutrophil elastase; sodium N-\[2-\[4-(2,2-dimethylpropionyloxy) phenyl-sulfonylaminobenzoyl\]amino-acetate tetrahydrate\]” NCT05697016 ↗ |
| Known as | SSH | “BACKGROUND: This study was undertaken to assess the value of administering perioperative sivelestat sodium hydrate (SSH), a selective neutrophil elastase inhibitor, after...” PMID 21557207 ↗ May 20111“Sivelestat Sodium Hydrate (SSH) combined with Ulinastatin (UTI)” PMID 38886709 ↗ Jun 2024 |
| Action | Inhibit | “a selective neutrophil elastase inhibitor” PMID 21557207 ↗ May 20111“Leukocyte elastase inhibitor” CHEMBL76688 ↗ |
| Modality | Small molecule | — CHEMBL76688 ↗ |
| Route | Intravenous | “0.2 mg/kg/hr continuous i.v. infusion - up to 14 days” NCT00219375 ↗ |
| Target | ELANE | “Leukocyte elastase inhibitor” CHEMBL76688 ↗ |