Drugs / rhTPO
last change Jun 2026 re-read 9 days ago

rhTPO

English name recombinant human thrombopoietin

Protein / enzyme biologic

Developed for
thrombocytopenia · thrombocytopenia due to immune destruction · acute myeloid leukemia · aplastic anemia · autoimmune thrombocytopenia · autoimmune thrombocytopenic purpura · acquired thrombocytopenia · cervical squamous cell carcinoma
+4 more · infectious disease with sepsis · myelodysplastic syndrome · plasma cell myeloma · sarcoma
Investigated by
Shandong University · Peking Union Medical College Hospital · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Huihan Wang · Institute of Hematology & Blood Diseases Hospital, China · Peking University People's Hospital
+76 more · Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Fudan University · Henan Cancer Hospital · Shandong Provincial Hospital · Shenyang Sunshine Pharmaceutical Co., LTD. · The First Affiliated Hospital of Dalian Medical University · The Second Hospital of Hebei Medical University · Anhui Medical University · Anqing Municipal Hospital · Beijing Public Health Foundation · Beijing Sanhuan Cancer Hospital · Bethune Charitable Foundation · Changhai Hospital · Children's Hospital of Soochow University · China Medical University, China · Chinese Academy of Medical Sciences · Chinese PLA General Hospital · First Affiliated Hospital Xi'an Jiaotong University · First Affiliated Hospital of Xinjiang Medical University · First Affiliated Hospital, Sun Yat-Sen University · Fosun Pharmaceutical Distribution Jiangsu co., Limited · Fujian Medical University Union Hospital · Hebei Medical University Fourth Hospital · Hebei Yanda Ludaopei Hospital · Henan Provincial People's Hospital · Huadong Hospital · JIANYANG WANG · Kashgar 1st People's Hospital · Liaoning Cancer Hospital & Institute · M.D. Anderson Cancer Center · Mei Feng · Ming Hou · Nanfang Hospital, Southern Medical University · North China University of Science and Technology · Peking Union Medical College · Peking University Shougang Hospital · People's Hospital of Xinjiang Uygur Autonomous Region · Qilu Hospital of Shandong University · Ruijin Hospital · Ruilan Wang · Second Affiliated Hospital of Guangzhou Medical University · Second Affiliated Hospital of Nanchang University · Second Hospital of Shanxi Medical University · Shaanxi Provincial People's Hospital · Shanghai Jiao Tong University School of Medicine · Shanghai Tongji Hospital, Tongji University School of Medicine · Shanghai University of Traditional Chinese Medicine · Shanxi Province Cancer Hospital · Shenyang Pharmaceutical University · Shenzhen Second People's Hospital · Southern Medical University, China · Sun Yat-sen University · The Affiliated Hospital of Inner Mongolia Medical University · The Affiliated Hospital of Qingdao University · The Affiliated Hospital of the Chinese Academy of Military Medical Sciences · The Affiliated People's Hospital of Ningbo University · The Affiliated Tumor Hospital of Nantong University, Nantong, Jiangsu Province, China · The First Affiliated Hospital of Nanchang University · The First Affiliated Hospital of Soochow University · The First People's Hospital of Yuhang District · The Second Affiliated Hospital of Dalian Medical University · The Second Affiliated Hospital of Harbin Medical University · The Second Affiliated Hospital of Kunming Medical University · The Third Xiangya Hospital of Central South University · Tianjin Medical University Cancer Institute and Hospital · Tianjin Medical University General Hospital · Tongji Hospital · Wang Guorong · West China Hospital · Xi'an Central Hospital · Xiangyang Central Hospital · Xijing Hospital · Yin Jie · Yuyao People's Hospital · all 82 on the full record

Trials 31

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT04518878 Aug 2020 → Dec 2021 thrombocytopenia due to immune destruction Peking University People's Hospital Unknown No outcome recorded
Phase 26 trials
Phase 2 NCT07334093 Jan 2026 → Nov 2027 expected acquired thrombocytopenia Sun Yat-sen University Not yet recruiting No outcome recorded
Phase 2 NCT06254287 Feb → Dec 2024 aplastic anemia Institute of Hematology & Blood Diseases Hospital, China Unknown No outcome recorded
Phase 2 NCT05944809 Jul 2023 → Jun 2024 esophageal cancer, thrombocytopenia JIANYANG WANG Completed No outcome recorded
Phase 2 NCT04516837 Aug 2020 → Aug 2021 thrombocytopenia due to immune destruction Peking University People's Hospital Unknown No outcome recorded
Phase 2 NCT03823079 Feb → Sep 2019 colorectal carcinoma, thrombocytopenia Fudan University Unknown No outcome recorded
Phase 2 NCT02857530 Aug 2016 → Jul 2019 aplastic anemia Tianjin Medical University General Hospital Unknown No outcome recorded
Phase 2/32 trials
Phase 2/3 NCT07848672 Jan 2027 → Dec 2029 expected thrombocytopenia The Affiliated People's Hospital of Ningbo University Not yet recruiting No outcome recorded
Phase 2/3 NCT02707497 Apr 2019 → Aug 2024 infectious disease with sepsis, thrombocytopenia Ruilan Wang Unknown No outcome recorded
Phase 312 trials · 1 met primary
Phase 3 NCT07653581 Jun 2026 → Dec 2028 expected myelodysplastic syndrome Peking Union Medical College Hospital Not yet recruiting No outcome recorded
Phase 3 NCT05382390 Jan 2022 → Jan 2024 acute myeloid leukemia Huihan Wang Unknown No outcome recorded
Phase 3 NCT05328804 Jan 2022 → Nov 2023 autoimmune thrombocytopenia Yin Jie Unknown No outcome recorded
Phase 3 NCT02487563 Oct 2015 → Apr 2019 thrombocytopenia The First Affiliated Hospital of Soochow University Completed Met primary
Phase 3 NCT02391272 Mar → Nov 2015 pregnancy disorder, thrombocytopenia due to immune destruction Shandong University Completed No outcome recorded
Phase 3 NCT02270801 Oct 2014 → Jan 2017 pregnancy disorder, thrombocytopenia due to immune destruction Shandong University Unknown No outcome recorded
Phase 3 NCT02244658 Sep 2014 → Jun 2017 acute myeloid leukemia, chemotherapy-induced toxicity, thrombocytopenia Shandong University Unknown No outcome recorded
Phase 3 NCT02203422 Jul 2014 → Jul 2015 autoimmune thrombocytopenia Shandong University Withdrawn No outcome recorded Stop: Enrollment
Phase 3 NCT01734057 Jul 2012 → Jul 2013 autoimmune thrombocytopenic purpura Shandong University Withdrawn No outcome recorded Stop: Enrollment
Phase 3 NCT01805648 Feb 2011 → Aug 2013 autoimmune thrombocytopenic purpura, thrombocytopenia due to immune destruction Peking Union Medical College Unknown No outcome recorded
Phase 46 trials · 1 met primary
Phase 4 NCT06525948 Jul 2024 → Jun 2025 overdue aplastic anemia Peking Union Medical College Hospital Not yet recruiting No outcome recorded
Phase 4 NCT06004791 Aug 2023 → Aug 2024 aplastic anemia Peking Union Medical College Hospital Unknown No outcome recorded
Phase 4 NCT05583838 Nov 2022 → Feb 2024 autoimmune thrombocytopenia Institute of Hematology & Blood Diseases Hospital, China Completed Met primary
Phase 4 NCT05411705 Jun 2022 → Jun 2024 thrombocytopenia The First Affiliated Hospital of Dalian Medical University Unknown No outcome recorded
Phase 4 NCT03771378 Jan 2019 → May 2020 autoimmune thrombocytopenia Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Unknown No outcome recorded
Phase 4 NCT03633019 Sep 2018 → Nov 2019 thrombocytopenia First Affiliated Hospital Xi'an Jiaotong University Unknown No outcome recorded
Phase not applicable4 trials
— NCT05258799 Jan 2022 → Jan 2024 acute myeloid leukemia Huihan Wang Unknown No outcome recorded
— NCT07649395 Feb 2021 → Jun 2024 cervical squamous cell carcinoma Mei Feng Completed No outcome recorded
— NCT04168138 Nov 2019 → Dec 2021 acute myeloid leukemia Huihan Wang Unknown No outcome recorded
— NCT02572596 Jan 2013 → Dec 2017 plasma cell myeloma Wang Guorong Unknown No outcome recorded
Comparator or background therapy1 trial
Phase 2/3 NCT04324060 Comparator Mar 2020 → Mar 2022 myelodysplastic syndrome Peking Union Medical College Hospital Unknown No outcome recorded

News releases announcing trial results or a regulatory action · 3

DateIssuerRelease
2026-06-15 Jiangsu HengRui Medicine Co., Ltd. Results 2026 EHA|恒瑞创新药海曲泊帕、立康可泮、泽美妥司他等10余项血液学最新研究成果亮相 hengrui.com ↗
海曲泊帕单药的血小板恢复效果与rhTPO单药相当。
2026-05-27 Shenyang Sunshine Pharmaceutical Co., LTD. Results EHA 2026|三生制药rhTPO与重组抗CD25人源化单克隆抗体4项研究入选,血小板减少症与造血干细胞移植管理临床数据即将公布 3sbio.com ↗
rhTPO 可有效改善 CAR-T 围治疗期重度血小板减少,半数患者 28 天内血小板恢复,高危评分及低基线血小板与恢复延迟、输血负荷高相关。
2026-05-27 Shenyang Sunshine Pharmaceutical Co., LTD. Results ASCO 2026|三生制药rhTPO与伊尼妥单抗4项研究入选,多瘤种血小板早期干预及乳腺癌新辅助治疗数据即将公布 3sbio.com ↗
宫颈鳞癌同步放化疗中,rhTPO 早期干预可显著提升血小板最低值、缩短血小板恢复时间、降低 G3-5 级重度血小板减少发生率,保障治疗不间断进行。

Evidence & citations 8 cited values

Every value below carries the sentence it was read from. 33 sources stand behind the page.

FieldValueCited text
Known as Rh-TPO “A Randomized Phase II Study of Recombinant Human Thrombopoietin (Rh-TPO) and Recombinant Human Interleukin-11 (rhIL-11) for Recurrent Colorectal Cancer (CRC) Patients With...” NCT03823079 ↗
32

NCT04518878 ↗

NCT02487563 ↗

NCT04168138 ↗

NCT05328804 ↗

NCT00283582 ↗

NCT03633019 ↗

NCT06525948 ↗

NCT02707497 ↗

NCT07334093 ↗

NCT05583838 ↗

Show 22 more sources

Known as recombinant human thrombopoietin “This is a multicenter, prospective, single-arm, phase II clinical study evaluating the early prophylactic use of recombinant human thrombopoietin (rhTPO) to prevent...” NCT07848672 ↗
13

“To explore the early intervention timing of recombinant human thrombopoietin (rhTPO) for cancer treatment-induced thrombocytopenia (CTIT) in cervical squamous cell carcinoma...” NCT07649395 ↗

“A Randomized Phase II Study of Recombinant Human Thrombopoietin (Rh-TPO) and Recombinant Human Interleukin-11 (rhIL-11) for Recurrent Colorectal Cancer (CRC) Patients With...” NCT03823079 ↗

“Recombinant human thrombopoietin (rhTPO) is a full-length glycosylated-TPO produced by Chinese hamster ovary cells, which showed its effectiveness in ITP in a variety of studies.” NCT04516837 ↗

“The aim of this study was to determine the safety and efficacy of recombinant human thrombopoietin (rhTPO) for the management of immune thrombocytopenia (ITP) during pregnancy.” PMID 28630121 ↗ Jun 2017

“Recombinant human thrombopoietin (rhTPO) is also a kind of a TPO receptor agonists which is highly specific platelet stimulating factor.” NCT04324060 ↗

“Recombinant Human Thrombopoietin,TPIAO®, Shenyang Sunshine Pharmaceutical Company Limited \[SUNSHINE\], Shenyang, China” NCT02707497 ↗

“subcutaneous injection of recombinant human thrombopoietin (rhTPO) 15000U once a week during the radiotherapy.” NCT05944809 ↗

“Recombinant human thrombopoietin (rhTPO), a full-length glycated TPO, is a recombinant form of c-Mpl ligand” NCT03771378 ↗

“Recombinant human thrombopoietin (rhTPO) is approved for thrombocytopenia after solid tumor chemotherapy” NCT04168138 ↗

“recombinant human thrombopoietin (rhTPO) + cyclosporine (CsA)” NCT07653581 ↗

Show 3 more sources

Known as Recombinant Human TPO “Recombinant Human TPO” NCT01805648 ↗
Known as TPIAO “Recombinant Human Thrombopoietin,TPIAO®, Shenyang Sunshine Pharmaceutical Company Limited \[SUNSHINE\], Shenyang, China” NCT02707497 ↗
Known as TPIAOTM “Rh-TPO (TPIAOTM, a product of Sunshine Pharmaceutical Co Ltd, China, approved by China State Food and Drug Administration)” NCT01506414 ↗
Action Activate “Both rhTPO and eltrombopag act on TPO receptors to increase platelets.” NCT03771378 ↗
Modality Protein / enzyme biologic “Recombinant Human Thrombopoietin” NCT00283582 ↗
Route Intravenous “intravenous rhTPO” NCT00283582 ↗