Drugs / Avenciguat
last change Jan 2026 re-read 2 minutes ago

Avenciguat

also known as BI 685509

Small molecule

Developed for
portal hypertension · diabetic kidney disease · liver disorder · chronic kidney disease · cirrhosis of liver · systemic sclerosis
Investigated by
Boehringer Ingelheim

Trials 15 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 19 trials
Phase 1 NCT06272058 May → Jul 2024 liver disorder Boehringer Ingelheim Terminated No outcome recorded
Phase 1 NCT06193811 Jan → Mar 2024 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT05515328 Sep → Nov 2022 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT03842761 Mar 2019 → Apr 2021 liver disorder Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT03165227 Oct 2017 → Dec 2019 diabetic kidney disease Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT03259464 Sep 2017 → May 2018 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT03116906 Apr 2017 → Jun 2018 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT03116893 Apr → May 2017 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT02694354 Mar → Apr 2016 Boehringer Ingelheim Completed No outcome recorded
Phase 26 trials
Phase 2 NCT06082843 Jan → May 2024 cirrhosis of liver, portal hypertension Boehringer Ingelheim Terminated No outcome recorded
Phase 2 NCT05559580 Dec 2022 → Oct 2025 systemic sclerosis Boehringer Ingelheim Completed No outcome recorded
Phase 2 NCT05282121 Jun 2022 → Apr 2024 portal hypertension Boehringer Ingelheim Terminated No outcome recorded
Phase 2 NCT05161481 Apr 2022 → May 2024 portal hypertension Boehringer Ingelheim Terminated No outcome recorded
Phase 2 NCT04750577 Apr 2021 → Nov 2022 diabetic kidney disease Boehringer Ingelheim Completed No outcome recorded
Phase 2 NCT04736628 Apr 2021 → Aug 2023 chronic kidney disease Boehringer Ingelheim Completed No outcome recorded

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 17 sources stand behind the page.

FieldValueCited text
Known as Avenciguat “Mass balance and absolute bioavailability of avenciguat ((14)C) after intravenous or oral administration in healthy male participants.” PMID 41489441 Jan 2026
7

NCT05559580

NCT06193811

NCT05282121

NCT06272058

NCT06082843

NCT05161481

NCT04736628

Known as BI 685509 “Avenciguat (BI 685509) is a medicine that is being developed to treat high blood pressure in the portal vein (main vessel going to the liver).” NCT06272058
10

“Avenciguat (BI 685509) TF2 (Reference, R) vs. Avenciguat (BI 685509) iCF (Test 1, T1) tablets under fasted conditions” NCT06193811

“Avenciguat (BI 685509)” NCT05161481

“Avenciguat (BI 685509)” NCT05559580

NCT03259464

NCT03165227

NCT04750577

NCT03116906

NCT02694354

NCT03116893

NCT03842761

Action Activate “BI 685509, a soluble guanylyl cyclase activator” PMID 38789635 May 2024
Modality Small molecule CHEMBL5314503
Route Oral “BI 685509 was rapidly absorbed after oral administration” PMID 38789635 May 2024