Drugs / Sacubitril/Valsartan
last change Jan 2025 re-read 2 minutes ago

Sacubitril/Valsartan

also known as ENTRESTO
Developed for
heart failure
Investigated by
DLR German Aerospace Center · Hannover Medical School

Trials 1 · a red edge is where a trial was stopped

201820192020202120222023202420252026
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 2 NCT03415906 Dec 2017 → Sep 2018 heart failure Hannover Medical School Withdrawn No outcome recorded

Press releases naming this drug 25 releases

DateIssuerRelease
2025-01-13 Novartis Pharmaceuticals Novartis Entresto® US patent upheld by US Court of Appeals novartis.com
2023-03-31 Novartis Pharmaceuticals Novartis Entresto receives positive CHMP opinion for pediatric heart failure novartis.com
2021-02-16 Novartis Pharmaceuticals Novartis Entresto® granted expanded indication in chronic heart failure by FDA novartis.com
2020-12-16 Novartis Pharmaceuticals Novartis announces positive FDA Advisory Committee recommendation for use of Entresto® to treat patients with HFpEF novartis.com
2019-11-17 Novartis Pharmaceuticals Novartis PARAGON-HF analyses suggest Entresto® benefit beyond HFrEF novartis.com
2019-09-02 Novartis Pharmaceuticals Entresto improved measures of heart structure and function in HFrEF patients in new Novartis study; additional data complement findings novartis.com
2019-09-01 Novartis Pharmaceuticals Novartis PARAGON-HF trial suggests Entresto® benefit in HFpEF patients but narrowly misses primary endpoint novartis.com
2019-08-19 Novartis Pharmaceuticals Novartis to present new Entresto HFpEF and HFrEF data at ESC Congress 2019 novartis.com
2018-11-11 Novartis Pharmaceuticals New Novartis study supports Entresto as foundational HFrEF therapy and in-hospital initiation in appropriate stabilized heart failure patients novartis.com
2018-08-25 Novartis Pharmaceuticals Novartis announces new data that show Entresto® (sacubitril/valsartan) can be initiated early & safely in hospitalized patients after an acute heart failure episode novartis.com
2018-05-28 Novartis Pharmaceuticals Novartis International AG: Patient-reported outcomes tool revealed significant improvement in symptom frequency and quality of life domains with Entresto® novartis.com
2018-04-16 Novartis Pharmaceuticals Novartis announces new analysis demonstrating Entresto helped preserve kidney function in patients with chronic heart failure, especially those with diabetes novartis.com

Evidence & citations 3 cited values

Every value below carries the sentence it was read from. 1 source stands behind the page.

FieldValueCited text
Known as Sacubitril/Valsartan “With Sacubitril/Valsartan (ENTRESTO®) on Centrally Generated Sympathetic Activity in Heart Failure Patients” NCT03415906
1

NCT03415906

Known as ENTRESTO “With Sacubitril/Valsartan (ENTRESTO®) on Centrally Generated Sympathetic Activity in Heart Failure Patients” NCT03415906
Action Inhibit “Combined angiotensin receptor + neprilysin inhibition” NCT03415906