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Drugs / Sodium Butyrate
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Sodium Butyrate

also known as butyric acid · sodium butylate

Small molecule

Developed for
acute graft versus host disease · cognitive impairment with or without cerebellar ataxia · hypertensive disorder · rheumatoid arthritis · schizophrenia · metabolic dysfunction-associated steatotic liver disease · poisoning · radiation-induced disorder
+1 more · shigellosis
Investigated by
City of Hope Medical Center · National Cancer Institute (NCI) · North Carolina Agriculture & Technical State University · North Carolina Translational and Clinical Sciences Institute · Peking University People's Hospital · Shanghai Mental Health Center
+3 more · Soonchunhyang University Hospital · Stanley Medical Research Institute · University of North Carolina, Chapel Hill

Trials 5

today NCT07611370 · Ph 1 NCT05808985 · Ph 2 NCT05576597 · Ph 2 NCT04415333 · Ph 1 NCT03010865 · Ph 2/3
2018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 12 trials
Phase 1 NCT07611370 Sep 2026 → Jun 2027 expected cancer, graft versus host disease, hematopoietic and lymphoid system neoplasm City of Hope Medical Center Not yet recruiting No outcome recorded
Phase 1 NCT04415333 Jul → Nov 2021 hypertensive disorder University of North Carolina, Chapel Hill Completed No outcome recorded
Phase 22 trials
Phase 2 NCT05808985 Sep 2022 → Sep 2023 acute graft versus host disease, butyrylesterase 1, post-bacterial disorder Soonchunhyang University Hospital Unknown No outcome recorded
Phase 2 NCT05576597 Aug 2022 → Oct 2023 rheumatoid arthritis Peking University People's Hospital Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT03010865 Jun 2017 → Dec 2019 cognitive impairment with or without cerebellar ataxia, schizophrenia Shanghai Mental Health Center Withdrawn No outcome recorded Stop: Business
Comparator or background therapy3 trials
Phase 1/2 NCT04700527 Comparator Dec 2023 → Apr 2027 expected poisoning, radiation-induced disorder UNC Lineberger Comprehensive Cancer Center Recruiting No outcome recorded
Phase 2 NCT00800930 Comparator Jan 2005 → Dec 2008 shigellosis International Centre for Diarrhoeal Disease Research, Bangladesh Completed No outcome recorded
Phase 3 NCT06759363 Comparator Jan → Dec 2024 metabolic dysfunction-associated steatotic liver disease University Medical Center Zvezdara Unknown No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 8 sources stand behind the page.

FieldValueCited text
Known as Sodium butyrate “Sodium butyrate and sodium propionate” NCT04700527 ↗
7

NCT06759363 ↗

NCT05808985 ↗

NCT05576597 ↗

NCT03010865 ↗

NCT07611370 ↗

NCT00800930 ↗

NCT04415333 ↗
Known as butyric acid “Take butyric acid (sodium butylate 600mg 2 tablets, BodyBio⒭, per day)” NCT05808985 ↗
Known as sodium butylate “Take butyric acid (sodium butylate 600mg 2 tablets, BodyBio⒭, per day)” NCT05808985 ↗
Action Activate “gene encoding LL-37 in cultured epithelial cell lines were up-regulated when treated with butyrate” NCT00800930 ↗
Modality Small molecule “Sodium butyrate is a short chain fatty acid and binds to the zinc site of histone deacetylases (HDAC).” NCT03010865 ↗
Route Rectal “butyrate enema 80 ml of 80 mM sodium butyrate, 12 hourly for 72 hours” NCT00800930 ↗