Drugs / Endostatin
last change Aug 2026 re-read 3 minutes ago

Endostatin

Protein / enzyme biologic

Developed for
nasopharyngeal carcinoma · non-small cell lung carcinoma · breast cancer · cancer of unknown primary site · acoustic neuroma · colorectal neoplasm · esophageal squamous cell carcinoma · female breast carcinoma
+5 more · gastroesophageal junction adenocarcinoma · melanoma · NF2-related schwannomatosis · pancreatic neuroendocrine tumor · refractory malignant neoplasm
Investigated by
Zhejiang Cancer Hospital · National Cancer Institute (NCI) · Sun Yat-sen University · Xijing Hospital · Affiliated Cancer Hospital & Institute of Guangzhou Medical University · Affiliated Hospital of Guangdong Medical University
+22 more · Beijing Tiantan Hospital · Fifth Affiliated Hospital, Sun Yat-Sen University · First Affiliated Hospital Xi'an Jiaotong University · Fujian Cancer Hospital · Fujian Province Tumor Hospital · Guangzhou General Hospital of Guangzhou Military Command · Hangzhou Cancer Hospital · Hebei Medical University Fourth Hospital · Peking Union Medical College Hospital · Peking University Cancer Hospital & Institute · Second Affiliated Hospital of Soochow University · Second Affiliated Hospital, School of Medicine, Zhejiang University · Shandong Simcere-Medgenn Bio-pharmaceutical Co., Ltd · Sir Run Run Shaw Hospital · The 458 Hospital of Chinese PLA · The Affiliated Tumor Hospital of Guangxi Medical University · Tianjin Medical University Cancer Institute and Hospital · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · University of Wisconsin, Madison · Xinqiao Hospital of Chongqing · Yun-fei Xia · Zhejiang University

Trials 22

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 12 trials
Phase 1 NCT00004872 Mar 2000 → ? cancer of unknown primary site University of Wisconsin, Madison Completed No outcome recorded
Phase 1 NCT00004229 Oct 1999 → Oct 2002 cancer of unknown primary site National Cancer Institute (NCI) Completed No outcome recorded
Phase 215 trials · 1 met primary
Phase 2 NCT06047860 Jun 2023 → Dec 2024 refractory malignant neoplasm Second Affiliated Hospital of Soochow University Unknown No outcome recorded
Phase 2 NCT05551247 Sep 2022 → Jun 2023 colorectal neoplasm First Affiliated Hospital Xi'an Jiaotong University Unknown No outcome recorded
Phase 2 NCT05514275 Aug 2022 → Aug 2026 overdue nasopharyngeal carcinoma Zhejiang Cancer Hospital Recruiting No outcome recorded
Phase 2 NCT05448781 Jul 2022 → Jul 2023 non-small cell lung carcinoma Affiliated Cancer Hospital & Institute of Guangzhou Medical University Unknown No outcome recorded
Phase 2 NCT05387681 May 2022 → Jul 2023 gastroesophageal junction adenocarcinoma Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Unknown No outcome recorded
Phase 2 NCT03917069 Mar 2019 → Sep 2021 melanoma Peking University Cancer Hospital & Institute Unknown No outcome recorded
Phase 2 NCT03461185 May 2018 → Aug 2019 non-small cell lung carcinoma Xinqiao Hospital of Chongqing Unknown No outcome recorded
Phase 2 NCT02745561 Jan 2016 → Dec 2017 Mammastatin, esophageal squamous cell carcinoma Hangzhou Cancer Hospital Unknown No outcome recorded
Phase 2 NCT02590133 Jul 2015 → Dec 2018 nasopharyngeal carcinoma Yun-fei Xia Unknown No outcome recorded
Phase 2 NCT02104323 Jan 2014 → Apr 2016 NF2-related schwannomatosis, acoustic neuroma Beijing Tiantan Hospital Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT01907529 Aug 2019 → Aug 2020 female breast carcinoma Hebei Medical University Fourth Hospital Unknown No outcome recorded
Phase 33 trials · 1 met primary
Phase 3 NCT02865304 Dec 2016 → Dec 2017 breast cancer Fujian Cancer Hospital Unknown No outcome recorded
Phase 3 NCT01915134 Aug 2013 → Jan 2016 chemotherapy-induced toxicity, nasopharyngeal carcinoma Zhejiang Cancer Hospital Unknown No outcome recorded
Phase 3 NCT01479036 Oct 2011 → Dec 2014 breast cancer Xijing Hospital Unknown Met primary
Phase 41 trial
Phase 4 NCT02497118 Aug 2010 → Apr 2015 non-small cell lung carcinoma Tianjin Medical University Cancer Institute and Hospital Completed No outcome recorded

Evidence & citations 9 cited values

Every value below carries the sentence it was read from. 25 sources stand behind the page.

FieldValueCited text
Known as endostatin “Endostar is a recombinant product of endostatin, which is an endogenous inhibitor of angiogenesis.” NCT02865304 ↗
21

“nab-paclitaxel 260mg/m2 d1+Carboplatin AUC=5 d1+ endostatin 15mg d1-14,q28d” NCT03917069 ↗

“Endostatin :210mg (14 doses), CIV continuously pumped for 72h, Q3W” NCT05387681 ↗

“Anti-Angiogenic Drugs contain endostatin, apatinib and anlotinib” NCT03461185 ↗

“human recombinant endostatin (endostar)” NCT01907529 ↗

NCT01845675 ↗

NCT00604435 ↗

NCT01915134 ↗

NCT00004872 ↗

NCT06047860 ↗

NCT02590133 ↗

Show 11 more sources

Known as endostar “Concurrently, recombinant human endostatin (Endostar) induces tumor vascular normalization and alleviates immunosuppression by inhibiting regulatory T cells (Tregs).” PMID 42291342 ↗ May 2026
4

“human recombinant endostatin (endostar) for breast cancer patients” NCT00604435 ↗

“with or without human recombinant endostatin (endostar)” NCT01479036 ↗

“human recombinant endostatin (endostar)” NCT01907529 ↗

“recombinant human endostatin (endostar)” NCT01915134 ↗

Known as Endostatin, Simcere-Medgenn (No. S20050088) “Endostatin, Simcere-Medgenn (No. S20050088)” NCT01479036 ↗
Known as human recombinant endostatin “human recombinant endostatin (endostar) for breast cancer patients” NCT00604435 ↗
Known as recombinant human endostatin “recombinant human endostatin (endostatin)” NCT05551247 ↗
Known as rh-endostatin “To further assess the efficacy and safety of recombinant human endostatin (rh-endostatin), a Phase III, multicenter, prospective, randomized, controlled clinical trial was conducted.” PMID 29238974 ↗ Dec 2017
1

“Recombinant human endostatin (rh-endostatin) is a novel antiangiogenesis drug developed in China.” PMID 23693018 ↗ May 2013

Action Inhibit “Endostatin is a multiple targeted angiogenesis inhibitor” NCT02590133 ↗
Modality Protein / enzyme biologic “Human Recombinant Endostatin” NCT00004229 ↗
Route Intravenous “Patients receive endostatin IV daily for 4 weeks.” NCT00004229 ↗