Preoperative Short Course Radiotherapy With Envafolimab, Endostatin and SOX Regimen in Locally Advanced Gastric

Phase 2 Unknown 35 enrolled Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

NaSingle-groupOpen-labelTreatment

Summary

This is a single-arm, exploratory clinical study to evaluate the efficacy and safety of Preoperative short course radiotherapy with Envafolimab, Endostatin and SOX regimen in resectable locally advanced gastric/gastroesophageal junction adenocarcinoma.

Timeline

Start: 2022-05-30
Primary completion: 2023-07-30
Completion: 2025-12-30

Publications

Results Li J, Deng Y, Zhang W, Zhou AP, Guo W, Yang J, Yuan Y, Zhu L, Qin S, Xiang S, Lu H, Gong J, Xu T, Liu D, Shen L. Subcutaneous envafolimab monotherapy in patients with advanced defective mismatch repair/microsatellite instability high solid tumors. J Hematol Oncol. 2021 Jun 21;14(1):95. doi: 10.1186/s13045-021-01095-1.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Endostar	Protein / enzyme biologic	210 mg	Intravenous
Subject	Envafolimab	Monoclonal antibody	300 mg	Subcutaneous

Preoperative Short Course Radiotherapy With Envafolimab, Endostatin and SOX Regimen in Locally Advanced Gastric

Summary

Timeline

Publications

Drugs

Indications