Drugs / Alosetron
Alosetron
also known as
A03AE01 · Alosetron hcl · Alosetron hydrochloride · GR 68755C · GR68755 · Lotronex · Lotrpnex
Small molecule targets HTR3A via inhibition
Regulatory milestones approvals, filings & regulatory actions · 4 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Label expansions (3) | US (FDA) | LOTRONEX | — | 2002-06-07 – 2008-04-01 | fda.gov ↗ |
| Approved | US (FDA) | LOTRONEX | — | 2000-02-09 | fda.gov ↗ |
Trials 4
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 21 trial | ||||||
| Phase 2 | NCT01855711 | Sep 2003 → May 2005 | irritable bowel syndrome | GlaxoSmithKline | Completed | No outcome recorded |
| Phase 32 trials | ||||||
| Phase 3 | NCT00067561 | Jun 2003 → Jan 2005 | irritable bowel syndrome | GlaxoSmithKline | Completed | No outcome recorded |
| Phase 3 | NCT00067457 | Jun 2003 → Dec 2005 | irritable bowel syndrome | GlaxoSmithKline | Completed | No outcome recorded |
| Phase 41 trial · 1 missed | ||||||
| Phase 4 | NCT00370032 | Dec 2006 → Dec 2007 | irritable bowel syndrome | GlaxoSmithKline | Completed | Missed primary |
Evidence & citations 11 cited values
Every value below carries the sentence it was read from. 5 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | alosetron | ClinicalTrials.gov intervention name — accepted as the source's own label NCT00067457 ↗ |
| Known as | A03AE01 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1110 ↗ |
| Known as | Alosetron hcl | ChEMBL registry synonym — accepted as the source's own label CHEMBL1110 ↗ |
| Known as | Alosetron hydrochloride | “GR68755 (Alosetron hydrochloride) 1 mg tablet” NCT01855711 ↗ |
| Known as | GR 68755C | ChEMBL registry synonym — accepted as the source's own label CHEMBL1110 ↗ |
| Known as | GR68755 | “GR68755 (Alosetron hydrochloride) 1 mg tablet” NCT01855711 ↗ |
| Known as | Lotronex | ChEMBL registry synonym — accepted as the source's own label CHEMBL1110 ↗ |
| Known as | Lotrpnex | ChEMBL registry synonym — accepted as the source's own label CHEMBL1110 ↗ |
| Action | Inhibit | “Serotonin 3a (5-HT3a) receptor antagonist” CHEMBL1110 ↗ |
| Modality | Small molecule | — CHEMBL1110 ↗ |
| Target | HTR3A | “Serotonin 3a (5-HT3a) receptor antagonist” CHEMBL1110 ↗ |