Drugs / Ritobegron
last change Dec 2005 re-read 2 minutes ago

Ritobegron

also known as KUC 7483 · KUC 7483 CL · Ritobegron Cl

Small molecule targets ADRB3 via activation

Developed for
overactive bladder
Investigated by
Boehringer Ingelheim · Kissei Pharmaceutical Co., Ltd.

Trials 6 · a red edge is where a trial was stopped

2003200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 13 trials
Phase 1 NCT02256722 Oct → Nov 2005 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT02256735 Aug → Dec 2005 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT02259907 May 2003 → Feb 2004 Boehringer Ingelheim Completed No outcome recorded
Phase 21 trial
Phase 2 NCT00742833 overactive bladder Kissei Pharmaceutical Co., Ltd. Completed No outcome recorded
Phase 32 trials
Phase 3 NCT01004315 overactive bladder Kissei Pharmaceutical Co., Ltd. Completed No outcome recorded
Phase 3 NCT01003405 overactive bladder Kissei Pharmaceutical Co., Ltd. Withdrawn No outcome recorded

Evidence & citations 8 cited values

Every value below carries the sentence it was read from. 7 sources stand behind the page.

FieldValueCited text
Known as ritobegron “Study to investigate the effect of Ritobegron CL (KUC 7483 CL) on the QT/QTc interval of the ECG in comparison to placebo and moxifloxacin” NCT02256735
1

“a single oral dose of 320 mg ritobegron administered alone or with a pre- and comedication with bisoprolol, propranolol and acipimox” NCT02256722

Known as KUC 7483 “Safety, Tolerability and Pharmacokinetics of Single Rising Oral Doses (40 to 400 mg) of KUC-7483 Tablets” NCT02259907
4

“Study to investigate safety, tolerability and pharmacokinetics of KUC 7483NCT02259907

NCT00742833

NCT01003405

NCT01004315

Known as KUC 7483 CL “Study to investigate the effect of Ritobegron CL (KUC 7483 CL) on the QT/QTc interval of the ECG in comparison to placebo and moxifloxacin” NCT02256735
Known as Ritobegron Cl “Study to investigate the effect of Ritobegron CL (KUC 7483 CL) on the QT/QTc interval of the ECG in comparison to placebo and moxifloxacin” NCT02256735
Action Activate “Beta-3 adrenergic receptor agonist” CHEMBL2107773
Modality Small molecule CHEMBL2107773
Route Oral “a single oral dose of 320 mg ritobegron administered alone” NCT02256722
Target ADRB3 “Beta-3 adrenergic receptor agonist” CHEMBL2107773