Drugs / Cenerimod
last change Mar 2026 re-read 9 days ago

Cenerimod

also known as ACT-334441

Small molecule targets S1PR1

Developed for
systemic lupus erythematosus · lupus nephritis
Investigated by
Viatris Innovation GmbH · Viatris Pharmaceuticals Co., Ltd.

Trials 14

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 17 trials
Phase 1 NCT07301723 Dec 2025 → Mar 2026 — Viatris Innovation GmbH Completed No outcome recorded
Phase 1 NCT05004311 Sep 2021 → Jul 2023 impaired renal function disease Viatris Innovation GmbH Completed No outcome recorded
Phase 1 NCT04819464 Aug 2021 → Aug 2024 — Viatris Innovation GmbH Completed No outcome recorded
Phase 1 NCT04255277 Jan 2020 → Sep 2021 — Viatris Innovation GmbH Completed No outcome recorded
Phase 1 NCT04052360 Aug → Oct 2019 — Viatris Innovation GmbH Completed No outcome recorded
Phase 1 NCT02914223 Sep → Dec 2016 — Viatris Innovation GmbH Completed No outcome recorded
Phase 1 NCT02479204 Apr 2015 → May 2016 — Viatris Innovation GmbH Terminated No outcome recorded
Phase 1/21 trial · 1 met primary
Phase 1/2 NCT02472795 Jun 2015 → Jan 2017 systemic lupus erythematosus Viatris Innovation GmbH Completed Met primary
Phase 22 trials · 1 missed
Phase 2 NCT07266090 Jan 2026 → Oct 2027 expected systemic lupus erythematosus Viatris Pharmaceuticals Co., Ltd. Active not recruiting No outcome recorded
Phase 2 NCT03742037 Dec 2018 → Aug 2021 systemic lupus erythematosus Viatris Innovation GmbH Completed Missed primary
Phase 34 trials
Phase 3 NCT07201129 Feb 2026 → Aug 2029 expected lupus nephritis, systemic lupus erythematosus Viatris Innovation GmbH Recruiting No outcome recorded
Phase 3 NCT06475742 Jul 2024 → Sep 2032 expected systemic lupus erythematosus Viatris Innovation GmbH Enrolling by invitation No outcome recorded
Phase 3 NCT05672576 Jun 2023 → Dec 2026 expected systemic lupus erythematosus Viatris Innovation GmbH Active not recruiting No outcome recorded
Phase 3 NCT05648500 Dec 2022 → Mar 2027 expected systemic lupus erythematosus Viatris Innovation GmbH Active not recruiting No outcome recorded

News releases announcing trial results or a regulatory action · 1

DateIssuerRelease
2024-12-18 Pfizer's Upjohn has merged with Mylan to form Viatris Inc. Results Viatris Announces Publication of Phase 2b CARE Study Data for Cenerimod in Lancet Rheumatology viatris.com ↗
The results, published in Lancet Rheumatology i , showed cenerimod 4 mg demonstrated clinically meaningful and sustained improvement from baseline on multiple measures of SLE disease activity compared to placebo, in addition to stable background SLE therapy.

All press releases naming this drug 1 release

DateIssuerRelease

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 15 sources stand behind the page.

FieldValueCited text
Known as Cenerimod ClinicalTrials.gov intervention name — accepted as the source's own label NCT07301723 ↗
12

NCT02472795 ↗

NCT07201129 ↗

NCT04052360 ↗

NCT04819464 ↗

NCT06475742 ↗

NCT02914223 ↗

NCT03742037 ↗

NCT07266090 ↗

NCT04255277 ↗

NCT05004311 ↗

Show 2 more sources

Known as ACT-334441 ClinicalTrials.gov intervention name — accepted as the source's own label NCT02479204 ↗
Modality Small molecule — CHEMBL4297505 ↗
Route Oral “Participants will receive cenerimod 0.5 mg capsules orally once daily for 12 weeks.” NCT02472795 ↗
Target S1PR1 “Sphingosine 1-phosphate receptor Edg-1 modulator” CHEMBL4297505 ↗