Drugs / Canrenone
Canrenone
also known as
Canrenona · NSC-261713 · SC-9376 · Spironolactone metabolite m1 · Spironolactone related compound a
Small molecule targets NR3C2 via inhibition
Trials 2
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 31 trial · 1 missed | ||||||
| Phase 3 | NCT00403910 | Sep 2002 → Jul 2006 | mild heart failure | Heart Care Foundation | Completed | Missed primary |
| Phase 41 trial · 1 missed | ||||||
| Phase 4 | NCT03536806 | Jun 2018 → Dec 2019 | paroxysmal atrial fibrillation | National Institute of Cardiology, Warsaw, Poland | Unknown | Missed primary |
| Comparator or background therapy1 trial | ||||||
| Phase 4 | NCT02687178 Comparator | Oct 2010 → Oct 2015 | essential hypertension | University of Pavia | Completed | No outcome recorded |
Evidence & citations 10 cited values
Every value below carries the sentence it was read from. 6 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Canrenone | ClinicalTrials.gov intervention name — accepted as the source's own label NCT02687178 ↗ |
| Known as | Canrenona | ChEMBL registry synonym — accepted as the source's own label CHEMBL1463345 ↗ |
| Known as | NSC-261713 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1463345 ↗ |
| Known as | SC-9376 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1463345 ↗ |
| Known as | Spironolactone metabolite m1 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1463345 ↗ |
| Known as | Spironolactone related compound a | ChEMBL registry synonym — accepted as the source's own label CHEMBL1463345 ↗ |
| Action | Inhibit | “canrenone, an aldosterone receptor antagonist” PMID 19147459 ↗ Jan 20091“Mineralocorticoid receptor antagonist” CHEMBL1463345 ↗ |
| Modality | Small molecule | — CHEMBL1463345 ↗ |
| Route | Intravenous | “Of all RAAS-inhibiting agents, only canrenone in the form of potassium canrenoate, a specific inhibitor of mineralocorticoid receptors, is administered intravenously.” PMID 40734383 ↗ Jul 2025 |
| Target | NR3C2 | “Mineralocorticoid receptor antagonist” CHEMBL1463345 ↗ |