Clinical Efficacy of Potassium Canrenoate in Sinus Rhythm Restoration Among Patients With Atrial Fibrillation.

Summary

The purpose of this randomized, double blind, placebo-controlled, superiority clinical trial was to assess clinical efficacy of potassium canrenoate - canrenone in rapid conversion of atrial fibrillation to sinus rhythm.

Timeline

Start

2018-06

Primary completion

2019-12

Completion

2020-12

Outcome

Missed primary endpoint

paper Intravenous canrenone is not effective in the sinus rhythm restoration among the patients with paroxysmal AF. PMID 40734383 ↗

Publications

• Dabrowski R, Segiet-Swiecicka A, Sawicki S, Kowalik I, Jaworski K, Farkowski M, Kubaszek-Kornatowska A, Michalek P, Dluzniewski M, Szwed H, Hryniewiecki T, Karwowski J; CANREN-AF investigators. Clinical Efficacy of Canrenone in Restoring Sinus Rhythm in Patients With Atrial Fibrillation-A Pilot, Randomized, Double-Blind Study. J Cardiovasc Pharmacol Ther. 2025 Jan-Dec;30:10742484251356361. doi: 10.1177/10742484251356361. Epub 2025 Jul 29.
• Dabrowski R, Syska P, Maczynska J, Farkowski M, Sawicki S, Kubaszek-Kornatowska A, Michalek P, Kowalik I, Szwed H, Hryniewiecki T. Clinical efficacy of potassium canreonate-canrenone in sinus rhythm restoration among patients with atrial fibrillation - a protocol of a pilot, randomized, double -blind, placebo-controlled study (CANREN-AF trial). Trials. 2020 May 12;21(1):397. doi: 10.1186/s13063-020-04277-3.

Drugs

Indications