Drugs / Racecadotril
Racecadotril
also known as
Acetorphan · Hidrasec · NSC-759828 · Racecadotril Granules · Racecadotrilo · Tiorfan · Tiorfix
Small molecule targets MME via inhibition
Trials 9
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 11 trial | ||||||
| Phase 1 | NCT05216822 | Jun → Jul 2018 | acute diarrhea | Assiut University | Completed | No outcome recorded |
| Phase 1/22 trials | ||||||
| Phase 1/2 | NCT07454421 | May 2026 → Dec 2027 expected | infectious disease with sepsis | Zhujiang Hospital | Enrolling by invitation | No outcome recorded |
| Phase 1/2 | NCT06529497 | Aug → Nov 2024 overdue | acute diarrhea | Liaquat National Hospital & Medical College | Not yet recruiting | No outcome recorded |
| Phase 33 trials | ||||||
| Phase 3 | NCT03473561 | Aug 2018 → Jan 2020 | infantile diarrhea | Abbott | Completed | No outcome recorded |
| Phase 3 | NCT03463512 | Mar → Sep 2018 | acute diarrhea | Abbott | Completed | No outcome recorded |
| Phase 3 | NCT01153854 | Jan 2007 → Jul 2008 | diarrheal disease | National Institute of Pediatrics, Mexico | Completed | No outcome recorded |
| Phase not applicable3 trials | ||||||
| — | NCT07392931 | Jun → Nov 2025 | acute diarrhea | Punjab Rangers Teaching Hospital Lahore | Completed | No outcome recorded |
| — | NCT05600062 | Mar 2023 → Feb 2026 overdue | acute respiratory distress syndrome | Queen Mary University of London | Active not recruiting | No outcome recorded |
| — | NCT04885049 | Sep 2021 → Feb 2022 | diarrheal disease | Shaheed Zulfiqar Ali Bhutto Medical University | Unknown | No outcome recorded |
| Comparator or background therapy3 trials | ||||||
| Phase 1 | NCT01948011 Comparator | Sep → Nov 2013 | — | Bioprojet | Completed | No outcome recorded |
| Phase 1 | NCT01476683 Comparator | Dec 2011 | diarrheal disease | McNeil AB | Completed | No outcome recorded |
| Phase 4 | NCT01577043 Comparator | Sep 2011 → Jan 2012 | acute diarrhea, gastroenteritis | Centro Pediatrico Albina de Patino | Completed | No outcome recorded |
Evidence & citations 12 cited values
Every value below carries the sentence it was read from. 13 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Racecadotril | ClinicalTrials.gov intervention name — accepted as the source's own label NCT01948011 ↗ |
| Known as | Acetorphan | ChEMBL registry synonym — accepted as the source's own label CHEMBL2103772 ↗ |
| Known as | Hidrasec | ChEMBL registry synonym — accepted as the source's own label CHEMBL2103772 ↗ |
| Known as | NSC-759828 | ChEMBL registry synonym — accepted as the source's own label CHEMBL2103772 ↗ |
| Known as | Racecadotril Granules | “Investigational drug: Racecadotril Granules” NCT07454421 ↗ |
| Known as | Racecadotrilo | “Since ten years ago, Racecadotrilo´s safety and efficacy had been proved.” NCT01153854 ↗ |
| Known as | Tiorfan | ChEMBL registry synonym — accepted as the source's own label CHEMBL2103772 ↗ |
| Known as | Tiorfix | ChEMBL registry synonym — accepted as the source's own label CHEMBL2103772 ↗ |
| Action | Inhibit | “inhibiting intestinal enkephalinase” NCT05216822 ↗1“Neprilysin inhibitor” CHEMBL2103772 ↗ |
| Modality | Small molecule | — CHEMBL2103772 ↗ |
| Route | Oral | “oral racecadotril” NCT01153854 ↗ |
| Target | MME | “Neprilysin inhibitor” CHEMBL2103772 ↗ |