Drugs / Polyethylene glycol 400
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Polyethylene glycol 400

also known as Macrogol 400
Developed for
dry eye syndrome · colonic disorder
Investigated by
Laboratorios Sophia S.A de C.V. · Andover Research Eye Institute · Calm Water Therapeutics LLC · Innovative Medical · University of Faisalabad

Trials 5

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 12 trials
Phase 1 NCT06375343 Jan 2026 → Jan 2027 expected dry eye syndrome Laboratorios Sophia S.A de C.V. Not yet recruiting No outcome recorded
Phase 1 NCT06379685 Dec 2025 → Dec 2026 expected dry eye syndrome Laboratorios Sophia S.A de C.V. Not yet recruiting No outcome recorded
Phase 41 trial
Phase 4 NCT00493662 — dry eye syndrome Innovative Medical Completed No outcome recorded
Phase not applicable2 trials
— NCT05660681 Dec 2022 → Aug 2023 dry eye syndrome Calm Water Therapeutics LLC Completed No outcome recorded
— NCT04970329 Jul 2021 dry eye syndrome University of Faisalabad Unknown No outcome recorded
Comparator or background therapy5 trials
Phase 4 NCT07676084 Comparator Jun → Oct 2026 expected dry eye syndrome Andover Research Eye Institute Recruiting No outcome recorded
Phase 4 NCT05292755 Comparator Apr → May 2022 dry eye syndrome University of Florida Completed Missed primary
Phase 4 NCT04708366 Comparator Feb 2021 → Mar 2022 colonic disorder University of Bologna Unknown No outcome recorded
Phase 4 NCT00756678 Comparator Sep 2008 → Aug 2009 dry eye syndrome Allergan Completed No outcome recorded
— NCT00681265 Comparator Jun → Aug 2008 dry eye syndrome Calm Water Therapeutics LLC Completed No outcome recorded

Evidence & citations 3 cited values

Every value below carries the sentence it was read from. 10 sources stand behind the page.

FieldValueCited text
Known as Polyethylene glycol 400 “Systane brand artificial tears containing 0.4% polyethylene glycol 400 and 0.3% propylene glycol will be self-administered three times a day in each eye by the participants for...” NCT05292755 ↗
8

“Propylene glycol 0.3% - Polyethylene glycol 400 0.5% - Glycerin 0.2%. Ophthalmic solution.” NCT06375343 ↗

“CWT-f-002: Active Ingredients are glycerin 0.7% and polyethylene glycol 400 0.4%.” NCT05660681 ↗

“Propylene glycol 0.3% - Polyethylene glycol 400 0.3%. Ophthalmic solution.” NCT06379685 ↗

“Polyethylene glycol 400” NCT00756678 ↗

NCT07676084 ↗

NCT00493662 ↗

NCT00681265 ↗

NCT04970329 ↗

Known as Macrogol 400 ClinicalTrials.gov intervention name — accepted as the source's own label NCT04708366 ↗
Route Topical “glycerin 0.7%/PEG 400 0.3% lubricant eye drops” NCT05660681 ↗