Drugs / Polyethylene glycol 400
last change Jun 2026 re-read 2 minutes ago

Polyethylene glycol 400

also known as Macrogol 400
Developed for
dry eye syndrome · colonic disorder
Investigated by
Laboratorios Sophia S.A de C.V. · Andover Research Eye Institute · Calm Water Therapeutics LLC · Innovative Medical · University of Faisalabad

Trials 5 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 12 trials
Phase 1 NCT06375343 Jan 2026 → Jan 2027 expected dry eye syndrome Laboratorios Sophia S.A de C.V. Not yet recruiting No outcome recorded
Phase 1 NCT06379685 Dec 2025 → Dec 2026 expected dry eye syndrome Laboratorios Sophia S.A de C.V. Not yet recruiting No outcome recorded
Phase 41 trial
Phase 4 NCT00493662 dry eye syndrome Innovative Medical Completed No outcome recorded
Phase not applicable2 trials
NCT05660681 Dec 2022 → Aug 2023 dry eye syndrome Calm Water Therapeutics LLC Completed No outcome recorded
NCT04970329 Jul 2021 dry eye syndrome University of Faisalabad Unknown No outcome recorded
Also used as a comparator or background therapy in 5 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 44 trials
Phase 4 NCT07676084 Comparator Jun → Oct 2026 expected dry eye syndrome Andover Research Eye Institute Recruiting No outcome recorded
Phase 4 NCT05292755 Comparator Apr → May 2022 dry eye syndrome University of Florida Completed No outcome recorded
Phase 4 NCT04708366 Comparator Feb 2021 → Mar 2022 colonic disorder University of Bologna Unknown No outcome recorded
Phase 4 NCT00756678 Comparator Sep 2008 → Aug 2009 dry eye syndrome Allergan Completed No outcome recorded
Phase not applicable1 trial
NCT00681265 Comparator Jun → Aug 2008 dry eye syndrome Calm Water Therapeutics LLC Completed No outcome recorded

Evidence & citations 3 cited values

Every value below carries the sentence it was read from. 10 sources stand behind the page.

FieldValueCited text
Known as Polyethylene glycol 400 “Systane brand artificial tears containing 0.4% polyethylene glycol 400 and 0.3% propylene glycol will be self-administered three times a day in each eye by the participants for...” NCT05292755
8

“Propylene glycol 0.3% - Polyethylene glycol 400 0.5% - Glycerin 0.2%. Ophthalmic solution.” NCT06375343

“CWT-f-002: Active Ingredients are glycerin 0.7% and polyethylene glycol 400 0.4%.” NCT05660681

“Propylene glycol 0.3% - Polyethylene glycol 400 0.3%. Ophthalmic solution.” NCT06379685

Polyethylene glycol 400NCT00756678

NCT04970329

NCT00493662

NCT00681265

NCT07676084

Known as Macrogol 400 ClinicalTrials.gov intervention name — accepted as the source's own label NCT04708366
Route Topical “glycerin 0.7%/PEG 400 0.3% lubricant eye drops” NCT05660681