drugset / Trial / NCT00681265
Tear Film Break-up Time After Instillation of Artificial Tears
RandomizedSingle-groupDouble-blindTreatment
Summary
This study is an exploratory trial evaluating the tear film break-up time after a single eye drop instillation of over-the-counter artificial tears. The primary hypothesis is that tear film break up time will be greater for test than control eye.
Timeline
- Start
- 2008-06
- Primary completion
- 2008-08
- Completion
- 2008-08
Publications
- Background Nichols JJ, Nichols KK, Puent B, Saracino M, Mitchell GL. Evaluation of tear film interference patterns and measures of tear break-up time. Optom Vis Sci. 2002 Jun;79(6):363-9. doi: 10.1097/00006324-200206000-00009.
- Background Ousler GW, Michaelson C, Christensen MT. An evaluation of tear film breakup time extension and ocular protection index scores among three marketed lubricant eye drops. Cornea. 2007 Sep;26(8):949-52. doi: 10.1097/ICO.0b013e3180de1c38.
- Background Cho P, Douthwaite W. The relation between invasive and noninvasive tear break-up time. Optom Vis Sci. 1995 Jan;72(1):17-22. doi: 10.1097/00006324-199501000-00004.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Glycerin | Other / unclassified | 1 % | Topical |
| Comparator | Polyethylene glycol 400 | Unknown | 0.4 % | Topical |
| Comparator | Propylene Glycol | Small molecule | 0.3 % | Topical |