Drugs / Propylene Glycol
Propylene Glycol
also known as
E-1520 · E490 · FEMA NO. 2940 · Ins no.1520 · Ins-1520 · Isopropylene glycol · Kilfrost abc-s · Kollisolv pg · +7 more
Trials 12 · a red edge is where a trial was stopped
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 12 trials | ||||||
| Phase 1 | NCT06375343 | Jan 2026 → Jan 2027 expected | dry eye syndrome | Laboratorios Sophia S.A de C.V. | Not yet recruiting | No outcome recorded |
| Phase 1 | NCT06379685 | Dec 2025 → Dec 2026 expected | dry eye syndrome | Laboratorios Sophia S.A de C.V. | Not yet recruiting | No outcome recorded |
| Phase 22 trials | ||||||
| Phase 2 | NCT06188260 | Jan → Nov 2024 | dry eye syndrome | The Hong Kong Polytechnic University | Completed | No outcome recorded |
| Phase 2 | NCT04380090 | Feb → Jul 2020 | constipation disorder | The Cleveland Clinic | Completed | No outcome recorded |
| Phase 31 trial | ||||||
| Phase 3 | NCT05116306 | Nov 2021 → Dec 2023 | tooth resorption | Ain Shams University | Unknown | No outcome recorded |
| Phase 43 trials | ||||||
| Phase 4 | NCT07451184 | Feb 2026 → May 2027 expected | dry eye syndrome | University of Waterloo | Recruiting | No outcome recorded |
| Phase 4 | NCT02322879 | May 2013 → Aug 2016 | paracetamol poisoning | Beth Israel Deaconess Medical Center | Completed | No outcome recorded |
| Phase 4 | NCT00493662 | — | dry eye syndrome | Innovative Medical | Completed | No outcome recorded |
| Phase not applicable4 trials | ||||||
| — | NCT06798025 | Jul 2023 → Jun 2024 | stenosis of lacrimal punctum | Tanta University | Completed | No outcome recorded |
| — | NCT04970329 | Jul 2021 | dry eye syndrome | University of Faisalabad | Unknown | No outcome recorded |
| — | NCT02446015 | Jun 2015 → Jun 2016 | dry eye syndrome | Alcon Research | Completed | No outcome recorded |
| — | NCT01967147 | Feb 2014 → Jan 2015 | dry eye syndrome | Alcon Research | Completed | No outcome recorded |
Also used as a comparator or background therapy in 5 trials
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 43 trials | ||||||
| Phase 4 | NCT07676084 Comparator | Jun → Oct 2026 expected | dry eye syndrome | Andover Research Eye Institute | Recruiting | No outcome recorded |
| Phase 4 | NCT05292755 Comparator | Apr → May 2022 | dry eye syndrome | University of Florida | Completed | No outcome recorded |
| Phase 4 | NCT03319420 Comparator | Mar 2018 → Jan 2021 | dry eye syndrome | Ocuwize LTD | Completed | No outcome recorded |
| Phase not applicable2 trials | ||||||
| — | NCT05660681 Comparator | Dec 2022 → Aug 2023 | dry eye syndrome | Calm Water Therapeutics LLC | Completed | No outcome recorded |
| — | NCT00681265 Comparator | Jun → Aug 2008 | dry eye syndrome | Calm Water Therapeutics LLC | Completed | No outcome recorded |
Evidence & citations 19 cited values
Every value below carries the sentence it was read from. 18 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Propylene Glycol | “Patients were treated with a combination of punctal dilation and topical medication in the form of preservative-free steroid eye drops based on dexamethasone sodium phosphate...” NCT06798025 ↗15“Our prior research indicates that inhibition of CYP 2E1 by administering a pediatric preparation of APAP containing Propylene Glycol (PG), a known CYP 2E1 inhibitor, results in...” NCT02322879 ↗ “Systane brand artificial tears containing 0.4% polyethylene glycol 400 and 0.3% propylene glycol will be self-administered three times a day in each eye by the participants for...” NCT05292755 ↗ “Propylene glycol 0.3% - Polyethylene glycol 400 0.5% - Glycerin 0.2%. Ophthalmic solution.” NCT06375343 ↗ “Propylene glycol 0.3% - Polyethylene glycol 400 0.3%. Ophthalmic solution.” NCT06379685 ↗ “Active Ingredients: Propylene Glycol 0.6% Purpose: Lubricant” NCT06188260 ↗ “Active Ingredients; Polyethylene Glycol Propylene Glycol” NCT03319420 ↗ |
| Known as | E-1520 | ChEMBL registry synonym — accepted as the source's own label CHEMBL286398 ↗ |
| Known as | E490 | ChEMBL registry synonym — accepted as the source's own label CHEMBL286398 ↗ |
| Known as | FEMA NO. 2940 | ChEMBL registry synonym — accepted as the source's own label CHEMBL286398 ↗ |
| Known as | Ins no.1520 | ChEMBL registry synonym — accepted as the source's own label CHEMBL286398 ↗ |
| Known as | Ins-1520 | ChEMBL registry synonym — accepted as the source's own label CHEMBL286398 ↗ |
| Known as | Isopropylene glycol | ChEMBL registry synonym — accepted as the source's own label CHEMBL286398 ↗ |
| Known as | Kilfrost abc-s | ChEMBL registry synonym — accepted as the source's own label CHEMBL286398 ↗ |
| Known as | Kollisolv pg | ChEMBL registry synonym — accepted as the source's own label CHEMBL286398 ↗ |
| Known as | Methyl glycol | ChEMBL registry synonym — accepted as the source's own label CHEMBL286398 ↗ |
| Known as | NSC-69860 | ChEMBL registry synonym — accepted as the source's own label CHEMBL286398 ↗ |
| Known as | PEG/PG | “artificial tear product (polyethylene glycol/propylene glycol [PEG/PG]; Systane Ultra)” PMID 29715369 ↗ May 2018 |
| Known as | polyethylene glycol/propylene glycol | “artificial tear product (polyethylene glycol/propylene glycol [PEG/PG]; Systane Ultra)” PMID 29715369 ↗ May 2018 |
| Known as | Propylene glycol (solvent) | ChEMBL registry synonym — accepted as the source's own label CHEMBL286398 ↗ |
| Known as | Propylene glycol dl-form | ChEMBL registry synonym — accepted as the source's own label CHEMBL286398 ↗ |
| Known as | Propyleneglycolum | ChEMBL registry synonym — accepted as the source's own label CHEMBL286398 ↗ |
| Action | Inhibit | “Propylene Glycol (PG), a known CYP 2E1 inhibitor” NCT02322879 ↗ |
| Modality | Small molecule | — CHEMBL286398 ↗ |
| Route | Oral | “one standard dose (17 grams) of an over-the-counter osmotic laxative (propylene glycol (PEG 3350), brand name Miralax) by mouth prior to discharge” NCT04380090 ↗ |