Drugs / Atuliflapon
last change Jan 2026 re-read 2 minutes ago

Atuliflapon

also known as AZD5718

Small molecule targets ALOX5AP via inhibition

Developed for
coronary artery disorder · chronic kidney disease · acute coronary syndrome · asthma
Investigated by
AstraZeneca · Parexel · Emerald Clinical Inc. · National University Heart Centre, Singapore · Quotient Sciences · University of Otago

Trials 13 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 19 trials
Phase 1 NCT04734275 Feb → Mar 2021 chronic kidney disease AstraZeneca Completed No outcome recorded
Phase 1 NCT04492709 Jul → Oct 2020 cardiovascular disorder AstraZeneca Completed No outcome recorded
Phase 1 NCT04210388 Jan → Mar 2020 coronary artery disorder AstraZeneca Completed No outcome recorded
Phase 1 NCT04087187 Sep → Oct 2019 coronary artery disorder AstraZeneca Completed No outcome recorded
Phase 1 NCT03948451 Apr → Jul 2019 cardiovascular disorder AstraZeneca Completed No outcome recorded
Phase 1 NCT03420092 Feb → Apr 2018 coronary artery disorder AstraZeneca Completed No outcome recorded
Phase 1 NCT03400488 Jan → Jun 2018 coronary artery disorder AstraZeneca Completed No outcome recorded
Phase 1 NCT02963116 Dec 2016 → Mar 2017 coronary artery disorder AstraZeneca Completed No outcome recorded
Phase 1 NCT02632526 Feb → Aug 2016 cardiovascular disorder AstraZeneca Completed No outcome recorded
Phase 24 trials
Phase 2 NCT05251259 Jan 2022 → Jan 2026 asthma AstraZeneca Completed No outcome recorded
Phase 2 NCT04601467 Jul 2021 → May 2024 acute coronary syndrome National University Heart Centre, Singapore Terminated No outcome recorded
Phase 2 NCT04492722 Oct 2020 → Sep 2022 chronic kidney disease AstraZeneca Terminated No outcome recorded
Phase 2 NCT03317002 Oct 2017 → Apr 2020 coronary artery disorder AstraZeneca Completed No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 15 sources stand behind the page.

FieldValueCited text
Known as Atuliflapon “Patients with an acute myocardial infarction (AMI) were randomized in a ratio of 1:1 ratio to receive AZD5718 (Atuliflapon) 125 mg or placebo for 12 months to assess the...” NCT04601467
1

NCT05251259

Known as AZD5718 “3 Doses of AZD5718NCT04087187
11

“Drug: AZD5718NCT04492709

NCT02963116

NCT04601467

NCT04210388

NCT03948451

NCT03400488

NCT04734275

NCT03420092

NCT04492722

NCT03317002

NCT02632526

Action Inhibit “AZD5718 is a FLAP inhibitor that dose-dependently reduced leukotriene biosynthesis in a first-in-human study.” PMID 31793171 Dec 2019
Modality Small molecule “AZD5718 is a first-in-class small-molecule anti-inflammatory drug” PMID 31793171 Dec 2019
Route Oral Oral suspension single dose” NCT02632526
Target ALOX5AP “5-lipoxygenase-activating protein inhibitor AZD5718” PMID 35842004 Jul 2022