Drugs / Carbimazole
last change Mar 2018 re-read 2 minutes ago

Carbimazole

Small molecule targets TPO via inhibition

Developed for
thyroid gland disorder
Investigated by
Barwon Health · National Health and Medical Research Council, Australia · University of Melbourne

Trials 1 · a red edge is where a trial was stopped

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PhaseRegistry idDatesIndicationSponsorStatusOutcome
NCT00430547 Aug 2003 → Jan 2006 disease of orbital part of eye adnexa Barwon Health Completed No outcome recorded
Also used as a comparator or background therapy in 2 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 3 NCT03303053 Comparator May 2017 → Mar 2018 Graves disease Clinical Research Centre, Malaysia Unknown No outcome recorded
Phase 3 NCT01436994 Comparator Jul 2004 → Dec 2014 thyroid gland disorder Newcastle-upon-Tyne Hospitals NHS Trust Completed No outcome recorded

Evidence & citations 9 cited values

Every value below carries the sentence it was read from. 4 sources stand behind the page.

FieldValueCited text
Known as Carbimazole “Tablet Carbimazole 30 mg daily, Tablet propanolol 40 mg twice daily for 4 weeks” NCT03303053
2

NCT00430547

NCT01436994

Known as Carbimazol ChEMBL registry synonym — accepted as the source's own label CHEMBL508102
Known as Carbimazol henning ChEMBL registry synonym — accepted as the source's own label CHEMBL508102
Known as Neo-mercazole 20 ChEMBL registry synonym — accepted as the source's own label CHEMBL508102
Known as Neo-mercazole 5 ChEMBL registry synonym — accepted as the source's own label CHEMBL508102
Known as NSC-758966 ChEMBL registry synonym — accepted as the source's own label CHEMBL508102
Action Inhibit “Anti thyroid drugs (ATDs) including methimazole, carbimazole, and propylthiouracil are effective treatments that inhibit thyroid hormone synthesis” NCT03303053
1

“Thyroid peroxidase inhibitor” CHEMBL508102

Modality Small molecule CHEMBL508102
Target TPO “Thyroid peroxidase inhibitor” CHEMBL508102