Innate Pharma to present adenosine franchise, IPH5201 and IPH5301 at ESMO IO 2022

Phase 1 data for IPH5201, a CD39-blocking monoclonal antibody, as monotherapy or in combination with durvalumab, in advanced solid tumors to be presented by partner AstraZeneca Preclinical data supporting rationale for the Phase 2 development of IPH5201 in non-small cell lung cancer will be presented Trial in Progress poster for IPH5301, a CD73-blocking monoclonal antibody investigated in collaboration with the Institut Paoli-Calmettes, will also be presented by the IPC Innate Pharma SA (Euronext Paris: IPH; Nasdaq: IPHA) (“ Innate ” or the “ Company ”) today announced that three posters showcasing IPH5201 and IPH5301 will be presented on December 8 at the 2022 European Society for Medical Oncology I-O (ESMO Immuno-Oncology) Annual Congress in Geneva, Switzerland. The following posters will be presented: IPH5201 as monotherapy or in combination with durvalumab in advanced solid tumors (AstraZeneca) Abstract Number: 472 Session Name: Poster Display 188P Session Time: 8 December, 12:30-13:15 Location: Palexpo exhibition centre – Foyer ABC Presenter: Dr. Martina Imbimbo, Head of Clinic for the Immuno-oncology Department within the Department of Oncology at UNIL CHUV (Lausanne, Switzerland) Combination of IPH5201, a block antibody targeting the CD39 immunosuppressive pathway, with durvalumab and chemotherapies: Preclinical rationale Abstract Number: 384 Session Name: Poster Display 190P Session Time: 8 December, 12:30-13:15 Location: Palexpo exhibition centre – Foyer ABC Presenter: Carine Paturel, Senior Director, Research and Drug Development, Products Portfolio Strategy, Innate Pharma (Marseille, France) A first-in-human phase I study of IPH5301, an anti-CD73 monoclonal antibody, alone or in combination with chemotherapy and trastuzumab, in patients with advanced solid tumors (CHANCES) (Institut Paoli-Calmettes) Abstract Number: 290 Session Name: Poster Display 199TiP Session Time: 8 December, 12:30-13:15 Location: Palexpo exhibition centre – Foyer ABC Presenter: Dr. Anthony Gonçalves, Professor of Medical Oncology, Institut Paoli-Calmettes (Marseille, France) The posters will be available on the Publications section of Innate’s website following the meeting. About IPH5201 IPH5201 is a CD39-blocking monoclonal antibody that may promote antitumor immunity by increasing immunostimulatory ATP and reducing immunosuppressive adenosine levels in the tumor microenvironment. It is being developed in partnership with AstraZeneca. A first-in-human, multi-centre, non-randomised, open-label, phase 1 study (NCT04261075) sponsored by AstraZeneca assessed the safety, efficacy, pharmacokinetics and pharmacodynamics of IPH5201 as monotherapy and in combination with durvalumab in patients with advanced solid tumors. A Phase 2 clinical trial conducted by Innate in lung cancer is in planning. About IPH5301 IPH5301 is a CD73-blocking monoclonal antibody currently in an investigator-sponsored Phase 1 trial in collaboration with the Institut Paoli-Calmettes (IPC) and Oncodistinct Network. By targeting the adenosine immunosuppressive pathway, IPH5301 has the potential to promote anti-tumor immune responses across a wide range of tumors. Subscribe to our newsletter Contact us 117, Avenue de Luminy - BP 30191 13 009 Marseille FRANCE +33 (0)4 30 30 30 30

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