ISIS-STAT3 Rx and ISIS-AR Rx Data Presented by AstraZeneca at European Cancer Symposium

CARLSBAD, Calif., Nov. 20, 2014 /PRNewswire/ -- Isis Pharmaceuticals, Inc. (NASDAQ: ISIS) announced today that data from two drugs in its anti-cancer franchise will be presented by researchers at AstraZeneca in three presentations at the 26th European Organization for Research and Treatment of Cancer (EORTC) – the National Cancer Institute (NCI) – and the American Association for Cancer Research (AACR) symposium. Results from a Phase 1/2 clinical study presented today provided preliminary evidence of antitumor activity for ISIS-STAT3Rx (AZD9150) in patients with cancer including advanced/metastatic hepatocellular carcinoma (HCC). This adds to previous data for ISIS-STAT3Rx showing evidence of antitumor activity in other cancer types, including diffuse large B cell lymphoma. Additional data to be presented at the conference demonstrate that ISIS-STAT3Rx reduced STAT3 levels in multiple cell types relevant to cancer growth and survival, clinically and pre-clinically. Based on these findings, as well as very encouraging preclinical data in animal models of cancer, AstraZeneca plans to evaluate ISIS-STAT3Rx as an immunomodulatory agent in combination with MEDI4736, AstraZeneca's investigational anti-PD-L1 immune checkpoint inhibitor. In addition, AstraZeneca will also present preclinical data on ISIS-ARRx (AZD5312) showing that the drug is active in several tumor models.

The release as fetched from its publisher. ionis.com ↗