EpicentRx Presents Poster on the Nephroprotective Effects of RRx-001 in Patients with Solid Tumors that Receive Cisplatin/Etoposide at the 2023 American Society of Clinical Oncology (ASCO) Genitourinary Cancers Symposium

TORREY PINES, Calif., February 15, 2023 — EpicentRx, Inc. (“EpicentRx”), a leading-edge, clinical-stage biopharmaceutical company that uses groundbreaking science to treat cancer and inflammatory-driven diseases, today announced that it has been selected for a poster presentation at the 2023 American Society of Clinical Oncology Genitourinary Cancers Symposium (ASCO) being held February 16-18 in San Francisco.The poster presents evidence of nephroprotective effects for RRx-001 in a 90 patient trial called QUADRUPLE THREAT where patients received cisplatin/etoposide + RRx-001 as treatment for small cell lung cancer (SCLC), high grade neuroendocrine cancers, HGNEC, non-small cell lung cancer (NSCLC), and ovarian cancer (OC). Details on the company’s poster presentation are below: Abstract Title : Effect of RRx-001 on nephrotoxicity of cisplatin/etoposide in patients with solid tumors. Session Title : Poster Session C: Renal Cell Cancer; Adrenal, Penile, Urethral and Testicular Cancers Abstract Number for Publication : 657 Session Date and Time : Saturday, February 18, 2023: 12:30 PM – 2 PM About RRx-001 RRx-001 is a highly selective NLRP3 inhibitor with vascular normalization and tumor associated macrophage polarization properties that resensitizes tumors to previously administered therapies. RRx-001 is under investigation in a Phase 3 trial for the treatment of small cell lung cancer (SCLC), and in a Phase 2 trial for protection against oral mucositis in first line head and neck cancer. It is also under development as a medical countermeasure for nuclear and radiological emergencies and as a treatment for neurodegenerative diseases like Parkinson’s and ALS/MND. About EpicentRx, Inc. EpicentRx is a leading-edge clinical-stage biopharmaceutical company with a complementary pipeline of small molecules, novel drug delivery devices, and cancer selective virus platforms that target inflammatory diseases of significant unmet need. For more information visit www.epicentrx.com . Media Contact Caitlin Chase, Associate Director, Taft Communications [email protected]

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