Results of an Open Label Dose Escalation Trial of AB-205 (E-CEL® cells) in Adults with Lymphoma Undergoing High-Dose Therapy and Autologous Hematopoietic Cell Transplantation (HDT-AHCT)

Abstract: HDT-AHCT is a standard potentially curative therapy for aggressive lymphomas. Despite improvements in supportive care, severe regimen-related toxicities (SRRT) are common and may limit use of HDT-AHCT. Frequently, SRRT involves the oral-gastrointestinal (oral/GI) tract as nausea, vomiting, diarrhea, and severe mucositis leading to high symptom burden, and increased risk for serious complications. AB-205 is an experimental engineered-cell therapy designed to accelerate regeneration of organs and eliminate or reduce SRRT. AB-205 contains E-CEL ® (allogeneic  E4 +  human umbilical vein endothelial) cells. Preclinical studies of E-CELs infused after conditioning have shown accelerated recovery of multiple organ functions. Transplantation & Cellular Therapy Meetings of ASTCT and CIBMTR – Monday, February 8, 2021 Lihua E. Budde, MD, PhD 1 , Michael Scordo, MD 2 , Mehrdad Abedi, MD 3 , Carolyn Mulroney, MD 4 , Bita Fakhri, MD, MPH 5 , Attaphol Pawarode, MD, PhD 6 , MI, Bhagirathbhai Dholaria, M.B.B.S. 7 , Geoffrey Shouse, DO, PhD 8 , Edward Kavalerchik, MD 9 , Sanjay H. Aggarwal, MD 9 , Muzaffar H. Qazilbash, MD 10 , Paul Finnegan, MD 9 , and Sergio A. Giralt, MD 2 1 City of Hope National Medical Center, Duarte, CA, 2 Department of Medicine, Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY, 3 Hematology/Oncology, UC Davis, Sacramento, CA, 4 Blood and Marrow Transplantation, UCSD Moores Cancer Center, La Jolla, CA, 5 Division of Hematology and Oncology, University of California San Francisco, San Francisco, CA, 6 Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI, 7 Hematology and Oncology, Vanderbilt University Medical Center, Nashville, TN, 8 Hematology and Hematopoietic Cell Transplantation, City of Hope Comprehensive Cancer Center, Duarte, CA, 9 Angiocrine Bioscience, San Diego, CA, 10 Stem Cell Transplantation & Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, TX, Go to TCT Meeting – 2021

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